Motor abnormalities (eg, dyskinesia, psychomotor slowing, neurological soft signs) are core
features of schizophrenia that occur independent of drug treatment and are associated with …

Cognitive impairments are core features of established schizophrenia spectrum disorders
(SSD). However, it remains unclear whether specific cognitive functions are differentially …

Importance Most patients with psychotic disorders experience severe cognitive impairment,
but the onset and course of this impairment remain unclear. Moreover, the course of …

Importance Childhood psychoticlike experiences (PLEs) are associated with greater odds of
a diagnosis of a psychotic disorder during adulthood. However, no known, well-validated …

Cognitive impairment is a core feature of schizophrenia but there is limited understanding of
the genetic relationship between cognition in the general population and schizophrenia. We …

Background Children with 22q11. 2 deletion syndrome (22q11. 2DS) have been reported to
have high rates of cognitive and psychiatric problems. Aims To establish the nature and …

Objective While psychotic experiences (PE s) are known to be associated with a range of
mental and general medical disorders, little is known about the association between PE s …

Introduction Identification of participants at clinical high-risk (CHR) for the development of
psychosis is an important objective of current preventive efforts in mental health research …

Brain changes in schizophrenia evolve along a dynamic trajectory, emerging before disease
onset and proceeding with ongoing illness. Recent investigations have focused attention on …

Aim Phenomena within the psychosis continuum that varies in frequency/duration/intensity
have been increasingly identified. Different terms describe these phenomena, however …