Irradiation of pharmaceuticals: A literature review

GP Jacobs - Radiation Physics and Chemistry, 2022 - Elsevier
Regulatory authorities require pharmaceuticals to be sterilized wherever practicable by a
terminal sterilization method that is sterilized in the final container rather than by aseptic …

EPR studies of free radicals decay and survival in gamma irradiated aminoglycoside antibiotics: sisomicin, tobramycin and paromomycin

S Wilczyński, B Pilawa, R Koprowski, Z Wróbel… - European Journal of …, 2012 - Elsevier
Radiation sterilization technology is more actively used now that any time because of its
many advantages. Gamma radiation has high penetrating power, relatively low chemical …

[PDF][PDF] Radiation effects on pharmaceuticals

G Abuhanoğlu, AY Özer - Fabad J. Pharm. Sci, 2010 - dergi.fabad.org.tr
Nowadays, sterilization process is used for the benefit of humans in different areas of daily
life. This includes the sterilisation of medical supplies and pharmaceuticals, in particular …

The influence of radiation sterilisation on some β-blockers in the solid state

B Marciniec, M Ogrodowczyk, B Czajka, M Hofman - Thermochimica acta, 2011 - Elsevier
Six derivatives of aryloxyalkylaminopropanol of known β-adrenolytic activity (acebutolol,
alprenolol, atenolol, metoprolol, pindolol, propranolol) in solid phase were exposed to the …

Analytical study on irradiated methylxanthine derivatives

B Marciniec, M Stawny, K Olszewski, M Kozak… - Journal of thermal …, 2013 - Springer
The effect of ionising radiation on the physico-chemical properties of three derivatives of
xanthine: caffeine, theophylline and theobromine, has been studied. The above-drugs in the …

Free radicals properties of gamma-irradiated penicillin-derived antibiotics: piperacillin, ampicillin, and crystalline penicillin

S Wilczyński, B Pilawa, R Koprowski, Z Wróbel… - Radiation and …, 2014 - Springer
The aim of this work was to determine the concentrations and properties of free radicals in
piperacillin, ampicillin, and crystalline penicillin after gamma irradiation. The radicals were …

Physicochemical stability of space medicines

PJ Mehta, D Bhayani - Handbook of Space Pharmaceuticals, 2022 - Springer
Astronauts' health and wellness maintenance in a unique, isolated, and extreme
environment of space is a primary goal for a successful space mission. Safe, efficacious, and …

Application of EPR spectroscopy for examination of free radical formation in thermally sterilized betamethasone, clobetasol, and dexamethasone

M Kościelniak-Ziemniak, B Pilawa - Applied Magnetic Resonance, 2012 - Springer
Paramagnetic centers in the three glucocorticosteroid drugs, such as betamethasone,
clobetasol, and dexamethasone, were examined by the use of X-band (9.3 GHz) electron …

Radiation sterilization as safe and effective way to obtain sterile biapenem

N Rosiak, K Kilińska, R Skibiński… - Radiation Physics and …, 2021 - Elsevier
Biapenem is parenteral carbapenem antibiotic with a broad spectrum of activity. The
objective of the study was to confirm that β-radiation irradiation with electron beam with a …

DSC and EPR analysis of some radiation sterilized alkaloids

B Marciniec, M Kozak, M Naskrent… - Journal of thermal …, 2010 - akjournals.com
The effect of ionising radiation on the physico-chemical properties of salts of three alkaloids
has been studied: codeine phosphate (COD), papaverine hydrochloride (PAP) and …