Biological dosimetry, based on the analysis of micronuclei (MN) in the cytokinesis-block
micronucleus (CBMN) assay can be used as an alternative method for scoring dicentric …

Micronuclei (MN) are small, extranuclear bodies that arise in dividing cells from acentric
chromosome/chromatid fragments or whole chromosomes/chromatids lagging behind in …

Micronuclei (MN) frequency is a biomarker of chromosomal damage, genome instability, and
cancer risk that integrates acquired mutations and genetic susceptibility. To evaluate and …

The micronucleus assay (MNT) in human lymphocytes is frequently used to assess
chromosomal damage as a consequence of environmental mutagen exposure, to assess …

BRCA1 and BRCA2 germline mutations are associated with a strong risk of breast cancer,
which may preclude breast-conserving treatment in carriers. This study examined whether …

As tumours in BRCA1/2 mutation carriers might be more sensitive to radiation, we
investigated after long-term follow-up whether mutation status influenced the rate of …

Cancer risk assessment is a multidisciplinary process that goes beyond the scope of
classical epidemiology to include the biological evaluation of individual differences to …

Background DNA repair pathways, cell cycle arrest checkpoints, and cell death induction are
present in cells to process DNA damage and prevent genomic instability caused by various …

Background High expression of constitutive histone γ-H2AX, a sensitive marker of DNA
damage, might be indicative of defective DNA repair pathway or genomic instability. 53BP1 …

The cytokinesis-block micronucleus assay in peripheral blood lymphocytes is a
standardised and validated technique for biodosimetry. Automated scoring of micronuclei …