Cytokine storm syndrome (CSS) has generally been described as a collection of clinical
manifestations resulting from an overactivated immune system. Cytokine storms (CSs) are …

Interleukin-1 (IL-1) is the prototypical inflammatory cytokine: two distinct ligands (IL-1α and IL-
1β) bind the IL-1 type 1 receptor (IL-1R1) and induce a myriad of secondary inflammatory …

IL-1 is a master cytokine of local and systemic inflammation. With the availability of specific
IL-1 targeting therapies, a broadening list of diseases has revealed the pathologic role of IL …

Neutrophilic dermatoses are a heterogeneous group of inflammatory skin disorders that
present with unique clinical features but are unified by the presence of a sterile …

Sweet's syndrome, also known as Acute Febrile Neutrophilic Dermatosis, is a rare
inflammatory condition. It is considered to be the prototype disease of neutrophilic …

The past 2 decades have seen a revolution in our approach to therapeutic
immunosuppression. We have moved from relying on broadly active traditional medications …

Neutrophil-mediated skin diseases, originally named neutrophilic dermatoses (NDs), are a
group of conditions due to an altered neutrophil recruitment and activation, characterized by …

Summary The interleukin (IL)‐1 family of cytokines is a central regulator of a myriad of
immunological responses. It comprises several cytokines, including those belonging to the …

Sweet syndrome is the most representative entity of febrile neutrophilic dermatoses. It
typically presents in patients with pirexya, neutrophilia, painful tender erytomatous papules …

Background Sweet syndrome is a neutrophilic dermatosis with cutaneous tender lesions that
can be associated with malignancies, infections, systemic inflammatory disorders, and …