The extended PP1 toolkit: designed to create specificity
Protein Ser/Thr phosphatase-1 (PP1) catalyzes the majority of eukaryotic protein
dephosphorylation reactions in a highly regulated and selective manner. Recent studies …
dephosphorylation reactions in a highly regulated and selective manner. Recent studies …
The PP1 binding code: a molecular‐lego strategy that governs specificity
E Heroes, B Lesage, J Görnemann… - The FEBS …, 2013 - Wiley Online Library
Ser/Thr protein phosphatase 1 (PP1) is a single‐domain hub protein with nearly 200
validated interactors in vertebrates. PP1‐interacting proteins (PIPs) are ubiquitously …
validated interactors in vertebrates. PP1‐interacting proteins (PIPs) are ubiquitously …
Protein serine/threonine phosphatases: keys to unlocking regulators and substrates
DL Brautigan, S Shenolikar - Annual review of biochemistry, 2018 - annualreviews.org
Protein serine/threonine phosphatases (PPPs) are ancient enzymes, with distinct types
conserved across eukaryotic evolution. PPPs are segregated into types primarily on the …
conserved across eukaryotic evolution. PPPs are segregated into types primarily on the …
An eIF2α-binding motif in protein phosphatase 1 subunit GADD34 and its viral orthologs is required to promote dephosphorylation of eIF2α
M Rojas, G Vasconcelos… - Proceedings of the …, 2015 - National Acad Sciences
Transient protein synthesis inhibition, mediated by phosphorylation of the α subunit of
eukaryotic translation initiation factor 2 (eIF2α), is an important protective mechanism cells …
eukaryotic translation initiation factor 2 (eIF2α), is an important protective mechanism cells …
Protein phosphatase 1 catalytic isoforms: specificity toward interacting proteins
L Korrodi-Gregório, SLC Esteves, M Fardilha - Translational Research, 2014 - Elsevier
The coordinated and reciprocal action of serine-threonine protein kinases and protein
phosphatases produces transitory phosphorylation, a fundamental regulatory mechanism for …
phosphatases produces transitory phosphorylation, a fundamental regulatory mechanism for …
Neuropilin-1 regulates a new VEGF-induced gene, Phactr-1, which controls tubulogenesis and modulates lamellipodial dynamics in human endothelial cells
B Allain, R Jarray, L Borriello, B Leforban, S Dufour… - Cellular signalling, 2012 - Elsevier
Recently, we identified a new Vascular Endothelial Growth Factor (VEGF)-A165-induced
gene Phactr-1,(Phosphatase Actin Regulator-1). We reported that Phactr-1 gene silencing …
gene Phactr-1,(Phosphatase Actin Regulator-1). We reported that Phactr-1 gene silencing …
ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail
MT Bertran, S Mouilleron, Y Zhou, R Bajaj… - Nature …, 2019 - nature.com
Serine/threonine phosphatases such as PP1 lack substrate specificity and associate with a
large array of targeting subunits to achieve the requisite selectivity. The tumour suppressor …
large array of targeting subunits to achieve the requisite selectivity. The tumour suppressor …
Synaptic NMDA receptor stimulation activates PP1 by inhibiting its phosphorylation by Cdk5
The serine/threonine protein phosphatase protein phosphatase 1 (PP1) is known to play an
important role in learning and memory by mediating local and downstream aspects of …
important role in learning and memory by mediating local and downstream aspects of …
Regulation of synaptic transmission and plasticity by protein phosphatase 1
Protein phosphatases, by counteracting protein kinases, regulate the reversible
phosphorylation of many substrates involved in synaptic plasticity, a cellular model for …
phosphorylation of many substrates involved in synaptic plasticity, a cellular model for …
Controlling Ser/Thr protein phosphatase PP1 activity and function through interaction with regulatory subunits
A Casamayor, J Ariño - Advances in Protein Chemistry and Structural …, 2020 - Elsevier
Protein phosphatase 1 is a major Ser/Thr protein phosphatase activity in eukaryotic cells. It
is composed of a catalytic polypeptide (PP1C), with little substrate specificity, that interacts …
is composed of a catalytic polypeptide (PP1C), with little substrate specificity, that interacts …