Tyrosinase plays a pivotal role in the synthesis of melanin pigment synthesis on skin utilizing
tyrosine as a substrate. Melanin is responsible for the protection against harmful ultraviolet …

Tyrosinase is a copper-containing oxidation enzyme, which is responsible for the production
of melanin. This enzyme is widely distributed in microorganisms, animals and plants, and …

For over half a century, the carbazole skeleton has been the key structural motif of many
biologically active compounds including natural and synthetic products. Carbazoles have …

Xanthine oxidase (XO), a versatile metalloflavoprotein enzyme, catalyzes the oxidative
hydroxylation of hypoxanthine and xanthine to uric acid in purine catabolism while …

Xanthine oxidase (XO) is the enzyme responsible for the catabolism of purines and their
conversion into uric acid. XO is thus the target for the treatment of hyperuricemia and gout …

Introduction: Xanthine oxidase (XO) is a versatile molybdoflavoprotein, widely distributed,
occurring in milk, kidney, lung, heart, and vascular endothelium. Catalysis by XO to produce …

9H-carbazole is an aromatic molecule that is tricyclic in nature, with two benzene rings fused
onto a 5-membered pyrrole ring. Obtained from natural sources or by synthetic routes, this …

Tyrosinase inhibitors have become increasingly important targets for hyperpigmentation
disease treatment. Kojic monooleate (KMO), synthesized from the esterification of kojic acid …

Xanthine oxidase (XO), an enzyme widely distributed among mammalian tissues, is
associated with the oxidation of xanthine and hypoxanthine to form uric acid. Reactive …

We have created a novel series of mushroom tyrosinase inhibitors with 1, 2, 4-triazole as
fundamental skeleton. The target compound 1, 2, 4-triazol-3-ylthio)-N-phenyl acetamide …