Motions in biomolecules are critical for biochemical reactions. In cells, many biochemical
reactions are executed inside of biomolecular condensates formed by ultradynamic …

It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

Phase separation is a ubiquitous and emerging mechanism underlying intracellular
organization. Yet how distinct molecular compositions in phase-separated condensates are …

Heat is of fundamental importance in many cellular processes such as cell metabolism, cell
division and gene expression. Accurate and noninvasive monitoring of temperature changes …

Significance: In all cells, the endoplasmic reticulum (ER) and mitochondria are physically
connected to form junctions termed mitochondria-associated membranes (MAMs). This …

Life emerges from thousands of biochemical processes occurring within a shared
intracellular environment. We have gained deep insights from in vitro reconstitution of …

Single-molecule methods have become widely used for quantifying the conformational
heterogeneity and structural dynamics of biomolecules in vitro. Their application in vivo …

Targeted hyperthermia treatment using magnetic nanoparticles is a promising cancer
therapy. However, the mechanisms of heat dissipation in the large alternating magnetic field …

Large-scale molecular dynamics simulations show that nanoparticle (NP) diffusivity in
weakly interacting mixtures of NPs and polymer melts has two very different classes of …

Cytokinesis is the process of physical cleavage at the end of cell division; it proceeds by
ingression of an acto-myosin furrow at the equator of the cell. Its failure leads to …