The cardiac conduction system (CCS) consists of distinctive components that initiate and
conduct the electrical impulse required for the coordinated contraction of the cardiac …

The molecular signatures of epigenetic regulation and chromatin architectures are
fundamental to genetically determined biological processes. Covalent and post-translational …

Myocardial infarction is a leading cause of death worldwide. Although advances have been
made in acute treatment, an incomplete understanding of remodelling processes has limited …

The heartbeat originates within the sinoatrial node (SAN), a small structure containing<
10,000 genuine pacemaker cells. If the SAN fails, the∼ 5 billion working cardiomyocytes …

The mammalian heart is the first functional organ, the first indicator of life. Its normal
formation and function are essential for fetal life. Defects in heart formation lead to …

During development, cardiogenesis is orchestrated by a family of heart progenitors that build
distinct regions of the heart. Each region contains diverse cell types that assemble to form …

Human pluripotent stem cells (PSCs) represent an attractive source of cardiomyocytes with
potential applications including disease modeling, drug discovery and safety screening, and …

The rate and rhythm of heart muscle contractions are coordinated by the cardiac conduction
system (CCS), a generic term for a collection of different specialized muscular tissues within …

Background: Myocardial mass is a key determinant of cardiac muscle function and
hypertrophy. Myocardial depolarization leading to cardiac muscle contraction is reflected by …

TBX3, a member of the ancient and evolutionary conserved T-box transcription factor family,
is a critical developmental regulator of several structures including the heart, mammary …