The formyl peptide receptors (FPRs) are G protein-coupled receptors that transduce
chemotactic signals in phagocytes and mediate host-defense as well as inflammatory …

Mammalian protein production platforms have had a profound impact in many areas of basic
and applied research, and an increasing number of blockbuster drugs are recombinant …

These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

Mass cytometry facilitates high-dimensional, quantitative analysis of the effects of bioactive
molecules on human samples at single-cell resolution, but instruments process only one …

Drug screening is often limited to cell-free assays involving purified enzymes, but it is
arguably best applied against systems that represent disease states or complex …

Resistance to antifungal drugs is an increasingly significant clinical problem. The most
common antifungal resistance encountered is efflux pump-mediated resistance of Candida …

In recent years, several novel aspects of GPCR pharmacology have been described, which
are thought to play a role in determining the in vivo efficacy of a compound. Fluorescent …

G protein-coupled receptors control a wide range of physiological processes and are the
target for many clinically used drugs. Understanding the way in which receptors bind …

As yeast cultures enter stationary phase in rich, glucose-based medium, differentiation of
two major subpopulations of cells, termed quiescent and nonquiescent, is observed …

Between 2004 and 2008, the US National Institutes of Health Molecular Libraries and
Imaging initiative pilot phase funded 10 high-throughput screening centers, resulting in the …