Treatments for Alzheimer's disease (AD) directed against the prominent amyloid plaque
neuropathology are yet to be proved effective despite many phase 3 clinical trials. There are …

Alzheimer's disease (AD) is a progressive neurodegenerative disease with a complex and
heterogeneous pathophysiology. The number of people living with AD is predicted to …

Glia have been implicated in Alzheimer's disease (AD) pathogenesis. Variants of the
microglia receptor triggering receptor expressed on myeloid cells 2 (TREM2) increase AD …

Alzheimer's disease (AD) is the most prevalent form of dementia, with complex
pathophysiology that is not fully understood. While β‐amyloid plaque and neurofibrillary …

Perturbations in iron homeostasis and iron accumulation feature in several
neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD) …

Abstract Nuclear receptor coactivator 4 (NCOA4) is a selective cargo receptor that mediates
the autophagic degradation of ferritin, the cytosolic iron storage complex, in a process …

Iron is an essential trace metal for almost all organisms, including human; however,
oxidative stress can easily be caused when iron is in excess, producing toxicity to the human …

Dynamic metabolic changes occurring in neurons are critically important in directing brain
plasticity and cognitive function. In other tissue types, disruptions to metabolism and the …

Cortical iron has been shown to be elevated in Alzheimer's disease (AD), but the impact of
the directly measured iron on the clinical syndrome has not been assessed. We investigated …

Allelic variation to the APOE gene confers the greatest genetic risk for sporadic Alzheimer's
disease (AD). Independent of genotype, low abundance of apolipoprotein E (apoE), is …