Flavonoids targeting HIF-1: Implications on cancer metabolism

M Samec, A Liskova, L Koklesova, S Mersakova… - Cancers, 2021 - mdpi.com
Simple Summary This comprehensive review discusses the anticancer effects of plant
phenolic compounds, known as flavonoids, through the targeting of HIF-1 and critical …

Up-regulation of key glycolysis proteins in cancer development

N Nowak, A Kulma, J Gutowicz - Open life sciences, 2018 - degruyter.com
In rapid proliferating cancer cells, there is a need for fast ATP and lactate production,
therefore cancer cells turn off oxidative phosphorylation and turn on the so called" Warburg …

DENDRO: genetic heterogeneity profiling and subclone detection by single-cell RNA sequencing

Z Zhou, B Xu, A Minn, NR Zhang - Genome biology, 2020 - Springer
Although scRNA-seq is now ubiquitously adopted in studies of intratumor heterogeneity,
detection of somatic mutations and inference of clonal membership from scRNA-seq is …

Proteomics analysis of meclofenamic acid‐treated small cell lung carcinoma cells revealed changes in cellular energy metabolism for cancer cell survival

S Yanar, M Kasap, A Kanli, G Akpinar… - … of Biochemical and …, 2023 - Wiley Online Library
Small cell lung carcinoma (SCLC) is a highly aggressive cancer with low survival rate.
Although initial response to chemotherapy in SCLC patients is well‐rated, the treatments …

Plasma proteome of growing tumors

S Gupta, MJ Westacott, DG Ayers, SJ Weiss… - Scientific Reports, 2023 - nature.com
Early detection of cancer is vital for the best chance of successful treatment, but half of all
cancers are diagnosed at an advanced stage. A simple and reliable blood screening test …

Enhancement of tryptic peptide signals from tissue sections using MALDI IMS postionization (MALDI-2)

JC McMillen, DB Gutierrez, AM Judd… - Journal of the …, 2021 - ACS Publications
Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) allows
for highly multiplexed, unlabeled mapping of analytes from tissue sections. However, further …

Investigating the Function of Human Jumping Translocation Breakpoint Protein (hJTB) and Its Interacting Partners through In-Solution Proteomics of MCF7 Cells

M Jayathirtha, D Whitham, S Alwine, M Donnelly… - Molecules, 2022 - mdpi.com
Human jumping translocation breakpoint (hJTB) gene is located on chromosome 1q21 and
is involved in unbalanced translocation in many types of cancer. JTB protein is ubiquitously …

Plasma proteome signature of canine acute haemorrhagic diarrhoea syndrome (AHDS)

L Huber, B Kuropka, PG Doulidis, E Baszler, L Martin… - Plos one, 2024 - journals.plos.org
Acute haemorrhagic diarrhoea is a common complaint in dogs. In addition to causes like
intestinal parasites, dietary indiscretion, intestinal foreign bodies, canine parvovirus …

[HTML][HTML] Proteomic profiling of metabolic proteins as potential biomarkers of radioresponsiveness for colorectal cancer

MZI Khan, SY Tam, Z Azam, HKW Law - Journal of proteomics, 2022 - Elsevier
Abstract Surgery, radiation therapy (RT), and chemotherapy are commonly used treatment
modalities for CRC management. The locally advanced CRC is managed with preoperative …

Antitumor activity of asperphenin B by induction of apoptosis and regulation of glyceraldehyde-3-phosphate dehydrogenase in human colorectal cancer cells

WS Byun, ES Bae, SC Park, WK Kim… - Journal of Natural …, 2021 - ACS Publications
Colorectal cancer (CRC) is a common and intractable malignancy with a high mortality risk.
Conventional chemotherapeutics are effective for patients with early stage CRC, but the …