The accumulation of protein inclusions is linked to many neurodegenerative diseases that
typically develop in older individuals, due to a combination of genetic and environmental …

Autophagy is an important biological process that is essential for the removal of damaged
organelles and toxic or aggregated proteins by delivering them to the lysosome for …

The Ensembl gene annotation system has been used to annotate over 70 different
vertebrate species across a wide range of genome projects. Furthermore, it generates the …

One of the most common lipids in the human body is palmitic acid (PA), a saturated fatty acid
with essential functions in brain cells. PA is used by cells as an energy source, besides …

The neurological diseases primarily include acute injuries, chronic neurodegeneration, and
others (eg, infectious diseases of the central nervous system). Autophagy is a housekeeping …

Posttranslational modifications of proteins are important regulatory processes endowing the
proteins functional complexity. Over the last decade, numerous studies have shed light on …

Protein S-palmitoylation refers to a post-translational modification (PTM) wherein palmitic
acid, a 16-carbon long saturated fatty acid gets covalently attached to Cys sidechain of a …

Protein S-palmitoylation is a reversible posttranslational modification of proteins with fatty
acids, an enzymatic process driven by a recently discovered family of protein …

Rationale: Glioblastoma multiforme (GBM) almost invariably gain invasive phenotype with
limited therapeutic strategy and ill-defined mechanism. By studying the aberrant expression …

One of the first molecular events in neurodegenerative diseases, regardless of etiology, is
protein mislocalization. Protein mislocalization in neurons is often linked to proteostasis …