Carbohydrates—namely glycans—decorate every cell in the human body and most secreted
proteins. Advances in genomics, glycoproteomics and tools from chemical biology have …

Simple Summary All cells are covered in a thick layer of sugar molecules known as glycans.
Changes to this sugar coat are common in cancer, and in particular cancer cells often …

The lower immunogenicity of synthetic subunit antigens, compared to live attenuated
vaccines, is being addressed with improved vaccine carriers. Recent reports indicate that …

Simple Summary Aberrant glycosylation is a common feature of many cancers, and it plays
crucial roles in tumor development and biology. Cancer progression can be regulated by …

Tumor cells exhibit striking changes in cell surface glycosylation as a consequence of
dysregulated glycosyltransferases and glycosidases. In particular, an increase in the …

Glycans–simple or complex carbohydrates–play key roles as recognition determinants and
modulators of numerous physiological and pathological processes. Thus, many …

Concurrent with US Food and Drug Administration (FDA) approval of the first therapeutic
cancer vaccine, a wide spectrum of other cancer vaccine platforms that target a diverse …

Tumor-associated carbohydrate antigens (TACA) result from the aberrant glycosylation that
is seen with transformation to a tumor cell. The carbohydrate antigens that have been found …

Quillaja saponaria Molina represents the main source of saponins for industrial applications.
Q. saponaria triterpenoids have been studied for more than four decades and their …

Therapeutic vaccination offers great promise as an intervention for a diversity of infectious
and non‐infectious conditions. Given that most chronic health conditions are thought to have …