Retinal development and maturation are orchestrated by a series of interacting signalling
networks that drive the morphogenetic transformation of the anterior developing brain …

Life on earth is subject to alternating cycles of day and night imposed by the rotation of the
earth. Consequently, living things have evolved photodetective systems to synchronize their …

The derivation of three-dimensional (3D) stratified neural retina from pluripotent stem cells
has permitted investigations of human photoreceptors. We have generated a H9 human …

Retinogenesis involves expansion of pluripotent progenitors, specification of postmitotic
precursors, and terminal differentiation. Rb or Rb/p107 loss causes retinoblastoma in …

Retinoblastomas result from the inactivation of the RB1 gene and the loss of Rb protein, yet
the cell type in which Rb suppresses retinoblastoma and the circuitry that underlies the need …

We previously reported that Otx2 is essential for photoreceptor cell fate determination;
however, the functional role of Otx2 in postnatal retinal development is still unclear although …

Rod and cone photoreceptors in the mammalian retina are special types of neurons that are
responsible for phototransduction, the first step of vision. Development and maintenance of …

Background: The visual system is now known to be composed of image-forming and non-
image-forming pathways. Photoreception for the image-forming pathway begins at the rods …

Leber congenital amaurosis (LCA) is the most common inherited cause of blindness in
childhood and is characterised by a severe retinal dystrophy before the age of one year. Six …

Retinal and macular degenerations are a major cause of blindness. Cell transplantation is a
possible therapeutic approach for the replacement of degenerating retinal cells. Here, we …