Ageing and the telomere connection: An intimate relationship with inflammation
J Zhang, G Rane, X Dai, MK Shanmugam… - Ageing research …, 2016 - Elsevier
Telomeres are the heterochromatic repeat regions at the ends of eukaryotic chromosomes,
whose length is considered to be a determinant of biological ageing. Normal ageing itself is …
whose length is considered to be a determinant of biological ageing. Normal ageing itself is …
Micronuclei frequency in peripheral blood lymphocytes and cancer risk: evidence from human studies
Over a century ago, Theodor Boveri paved the way to mechanistic studies linking
chromosomal abnormalities to cancer pathogenesis. Since then, theoretical and empirical …
chromosomal abnormalities to cancer pathogenesis. Since then, theoretical and empirical …
The HUman MicroNucleus Project—an international collaborative study on the use of the micronucleus technique for measuring DNA damage in humans
The International Collaborative Project on Micronucleus Frequency in Human Populations
(HUMN) was organized to collect data on micronucleus (MN) frequencies in different human …
(HUMN) was organized to collect data on micronucleus (MN) frequencies in different human …
Formaldehyde exposure and leukemia: a new meta-analysis and potential mechanisms
Formaldehyde is an economically important chemical, to which more than 2 million US
workers are occupationally exposed. Substantially more people are exposed to …
workers are occupationally exposed. Substantially more people are exposed to …
The role of folic acid and Vitamin B12 in genomic stability of human cells
M Fenech - … Research/Fundamental and Molecular Mechanisms of …, 2001 - Elsevier
Folic acid plays a critical role in the prevention of chromosome breakage and
hypomethylation of DNA. This activity is compromised when Vitamin B12 (B12) …
hypomethylation of DNA. This activity is compromised when Vitamin B12 (B12) …
Chromosomal aberrations in lymphocytes predict human cancer independently of exposure to carcinogens
S Bonassi, L Hagmar, U Strömberg, AH Montagud… - Cancer Research, 2000 - AACR
An increased risk of cancer in healthy individuals with high levels of chromosomal
aberrations (CAs) in peripheral blood lymphocytes has been described in recent …
aberrations (CAs) in peripheral blood lymphocytes has been described in recent …
Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22 358 subjects in 11 countries
Mechanistic evidence linking chromosomal aberration (CA) to early stages of cancer has
been recently supported by the results of epidemiological studies that associated CA …
been recently supported by the results of epidemiological studies that associated CA …
Chromosomal aberrations: formation, identification and distribution
G Obe, P Pfeiffer, JRK Savage, C Johannes… - Mutation Research …, 2002 - Elsevier
Chromosomal aberrations (CA) are the microscopically visible part of a wide spectrum of
DNA changes generated by different repair mechanisms of DNA double strand breaks …
DNA changes generated by different repair mechanisms of DNA double strand breaks …
Chromosomal aberrations and SCEs as biomarkers of cancer risk
Previous studies have suggested that the frequency of chromosomal aberrations (CAs), but
not of sister chromatid exchanges (SCEs), predicts cancer risk. We have further examined …
not of sister chromatid exchanges (SCEs), predicts cancer risk. We have further examined …
Genetic susceptibility to lung cancer: the role of DNA damage and repair
It has long been recognized that people differ in their susceptibility to disease. Some of
these differences are ascribed to the concept that heritable traits modify the effects of …
these differences are ascribed to the concept that heritable traits modify the effects of …