Activity‐based sensing: a synthetic methods approach for selective molecular imaging and beyond

KJ Bruemmer, SWM Crossley… - Angewandte Chemie …, 2020 - Wiley Online Library
Emerging from the origins of supramolecular chemistry and the development of selective
chemical receptors that rely on lock‐and‐key binding, activity‐based sensing (ABS)—which …

Bacterial Metallostasis: Metal Sensing, Metalloproteome Remodeling, and Metal Trafficking

DA Capdevila, JJ Rondón, KA Edmonds… - Chemical …, 2024 - ACS Publications
Transition metals function as structural and catalytic cofactors for a large diversity of proteins
and enzymes that collectively comprise the metalloproteome. Metallostasis considers all …

Ferrous iron-dependent pharmacology

RL Gonciarz, EA Collisson, AR Renslo - Trends in pharmacological …, 2021 - cell.com
The recent emergence of oxidation state selective probes of cellular iron has produced a
more nuanced understanding of how cells utilize this crucial nutrient to empower enzyme …

Emerging role of ferrous iron in bacterial growth and host–pathogen interaction: New tools for chemical (micro) biology and antibacterial therapy

RL Gonciarz, AR Renslo - Current opinion in chemical biology, 2021 - Elsevier
Chemical tools capable of detecting ferrous iron with oxidation-state specificity have only
recently become available. Coincident with this development in chemical biology has been …

Iron Acquisition by Bacterial Pathogens: Beyond tris‐Catecholate Complexes

Y Zhang, S Sen, DP Giedroc - ChemBioChem, 2020 - Wiley Online Library
Sequestration of the essential nutrient iron from bacterial invaders that colonize the
vertebrate host is a central feature of nutritional immunity and the “fight over transition …

Aktivitätsbasierte Sensorik: ein synthetisch‐methodischer Ansatz für die selektive molekulare Bildgebung und darüber hinaus.

KJ Bruemmer, SWM Crossley… - Angewandte Chemie, 2020 - Wiley Online Library
Die Ursprünge der aktivitätsbasierten Sensorik (ABS) liegen in der supramolekularen
Chemie und der Entwicklung selektiver chemischer Rezeptoren nach dem Schlüssel …

The Hydroxypyridinone Iron Chelator DIBI Reduces Bacterial Load and Inflammation in Experimental Lung Infection

X Zhang, R Nickerson, L Burton, A Stueck, B Holbein… - Biomedicines, 2024 - mdpi.com
Iron plays a critical role in lung infections due to its function in the inflammatory immune
response but also as an important factor for bacterial growth. Iron chelation represents a …

Carbohydrate de-N-acetylases acting on structural polysaccharides and glycoconjugates

S Pascual, A Planas - Current Opinion in Chemical Biology, 2021 - Elsevier
Deacetylation of N-acetylhexosamine residues in structural polysaccharides and
glycoconjugates is catalyzed by different families of carbohydrate esterases that, despite …

Cyclic peroxides as prodrugs for selective delivery of agents

AR Renslo, EMW Lauterwasser, SD Fontaine… - US Patent …, 2020 - Google Patents
2019-06-26 Assigned to THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
reassignment THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ASSIGNMENT OF …

Cyclic peroxides as prodrugs for selective delivery of agents

AR Renslo, EMW Lauterwasser, SD Fontaine… - US Patent …, 2021 - Google Patents
2020-11-19 Assigned to THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
reassignment THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ASSIGNMENT OF …