Epigenetic modifications in schizophrenia and related disorders: molecular scars of environmental exposures and source of phenotypic variability
J Richetto, U Meyer - Biological Psychiatry, 2021 - Elsevier
Epigenetic modifications are increasingly recognized to play a role in the etiology and
pathophysiology of schizophrenia and other psychiatric disorders with developmental …
pathophysiology of schizophrenia and other psychiatric disorders with developmental …
The role of brain microvascular endothelial cell and blood-brain barrier dysfunction in schizophrenia
S Pong, R Karmacharya, M Sofman, JR Bishop… - Complex …, 2020 - karger.com
Background: Despite decades of research, little clarity exists regarding pathogenic
mechanisms related to schizophrenia. Investigations on the disease biology of …
mechanisms related to schizophrenia. Investigations on the disease biology of …
The effect of polygenic risk scores for major depressive disorder, bipolar disorder and schizophrenia on morphological brain measures: a systematic review of the …
Background Major depressive disorder (MDD), bipolar disorder (BD) and schizophrenia
(SCZ) share clinical features and genetic bases. Magnetic Resonance Imaging (MRI) …
(SCZ) share clinical features and genetic bases. Magnetic Resonance Imaging (MRI) …
Public attitudes, interests, and concerns regarding polygenic embryo screening
Importance Polygenic embryo screening (PES) is a novel technology that estimates the
likelihood of developing future conditions (eg, diabetes or depression) and traits (eg, height …
likelihood of developing future conditions (eg, diabetes or depression) and traits (eg, height …
Mental health is biological health: Why tackling “diseases of the mind” is an imperative for biological anthropology in the 21st century
The germ theory of disease and the attendant public health initiatives, including sanitation,
vaccination, and antibiotic treatment, led to dramatic increases in global life expectancy. As …
vaccination, and antibiotic treatment, led to dramatic increases in global life expectancy. As …
[HTML][HTML] Cancer rates and mortality in people with severe mental illness: Further evidence of lack of parity
N Launders, L Scolamiero, DPJ Osborn… - Schizophrenia Research, 2022 - Elsevier
Background Severe mental illness (SMI) is associated with poorer physical health, however
the relationship between SMI and cancer is complex and previous study findings are …
the relationship between SMI and cancer is complex and previous study findings are …
Alterations of perineuronal nets in the dorsolateral prefrontal cortex of neuropsychiatric patients
J Alcaide, R Guirado, C Crespo… - International journal of …, 2019 - Springer
Background Alterations in the structure and physiology of interneurons in the prefrontal
cortex (PFC) are important factors in the etiopathology of different psychiatric disorders …
cortex (PFC) are important factors in the etiopathology of different psychiatric disorders …
Differential brain ADRA2A and ADRA2C gene expression and epigenetic regulation in schizophrenia. Effect of antipsychotic drug treatment
I Brocos-Mosquera, P Miranda-Azpiazu… - Translational …, 2021 - nature.com
Postsynaptic α2A-adrenoceptor density is enhanced in the dorsolateral prefrontal cortex
(DLPFC) of antipsychotic-treated schizophrenia subjects. This alteration might be due to …
(DLPFC) of antipsychotic-treated schizophrenia subjects. This alteration might be due to …
The adenosine hypothesis of schizophrenia into its third decade: From neurochemical imbalance to early life etiological risks
P Singer, BK Yee - Frontiers in Cellular Neuroscience, 2023 - frontiersin.org
The adenosine hypothesis of schizophrenia was conceptualized about two decades ago in
an attempt to integrate two prominent theories of neurochemical imbalance that attribute the …
an attempt to integrate two prominent theories of neurochemical imbalance that attribute the …
Disease-specific differences in gene expression, mitochondrial function and mitochondria-endoplasmic reticulum interactions in iPSC-derived cerebral organoids and …
A Kathuria, K Lopez-Lengowski, D McPhie… - Discover Mental …, 2023 - Springer
We compared transcriptomic profiles of cerebral organoids differentiated from induced
pluripotent stem cells of eight schizophrenia and eight bipolar disorder patients to identify …
pluripotent stem cells of eight schizophrenia and eight bipolar disorder patients to identify …