Epigenetic modifications are increasingly recognized to play a role in the etiology and
pathophysiology of schizophrenia and other psychiatric disorders with developmental …

Background: Despite decades of research, little clarity exists regarding pathogenic
mechanisms related to schizophrenia. Investigations on the disease biology of …

Background Major depressive disorder (MDD), bipolar disorder (BD) and schizophrenia
(SCZ) share clinical features and genetic bases. Magnetic Resonance Imaging (MRI) …

Importance Polygenic embryo screening (PES) is a novel technology that estimates the
likelihood of developing future conditions (eg, diabetes or depression) and traits (eg, height …

The germ theory of disease and the attendant public health initiatives, including sanitation,
vaccination, and antibiotic treatment, led to dramatic increases in global life expectancy. As …

Background Severe mental illness (SMI) is associated with poorer physical health, however
the relationship between SMI and cancer is complex and previous study findings are …

Background Alterations in the structure and physiology of interneurons in the prefrontal
cortex (PFC) are important factors in the etiopathology of different psychiatric disorders …

Postsynaptic α2A-adrenoceptor density is enhanced in the dorsolateral prefrontal cortex
(DLPFC) of antipsychotic-treated schizophrenia subjects. This alteration might be due to …

The adenosine hypothesis of schizophrenia was conceptualized about two decades ago in
an attempt to integrate two prominent theories of neurochemical imbalance that attribute the …

We compared transcriptomic profiles of cerebral organoids differentiated from induced
pluripotent stem cells of eight schizophrenia and eight bipolar disorder patients to identify …