New insights into the evasion of host innate immunity by Mycobacterium tuberculosis

Q Chai, L Wang, CH Liu, B Ge - Cellular & molecular immunology, 2020 - nature.com
Mycobacterium tuberculosis (Mtb) is an extremely successful intracellular pathogen that
causes tuberculosis (TB), which remains the leading infectious cause of human death. The …

Microbiome, inflammation, epigenetic alterations, and mental diseases

R Alam, HM Abdolmaleky… - American Journal of …, 2017 - Wiley Online Library
Major mental diseases such as autism, bipolar disorder, schizophrenia, and major
depressive disorder are debilitating illnesses with complex etiologies. Recent findings show …

A mycobacterial effector promotes ferroptosis-dependent pathogenicity and dissemination

L Qiang, Y Zhang, Z Lei, Z Lu, S Tan, P Ge… - Nature …, 2023 - nature.com
Ferroptosis is a lipid peroxidation-driven and iron-dependent programmed cell death
involved in multiple physical processes and various diseases. Emerging evidence suggests …

Post-translational protein acetylation: an elegant mechanism for bacteria to dynamically regulate metabolic functions

DG Christensen, X Xie, N Basisty, J Byrnes… - Frontiers in …, 2019 - frontiersin.org
Post-translational modifications (PTM) decorate proteins to provide functional heterogeneity
to an existing proteome. The large number of known PTMs highlights the many ways that …

Novel In Silico mRNA vaccine design exploiting proteins of M. tuberculosis that modulates host immune responses by inducing epigenetic modifications

H Al Tbeishat - Scientific Reports, 2022 - nature.com
Tuberculosis is an airborne infectious disease caused by Mycobacterium tuberculosis. BCG
is the only approved vaccine. However, it has limited global efficacy. Pathogens could affect …

Secretory proteins of Mycobacterium tuberculosis and their roles in modulation of host immune responses: focus on therapeutic targets

R Pal, MK Bisht, S Mukhopadhyay - The FEBS Journal, 2022 - Wiley Online Library
Mycobacterium tuberculosis, the bacterium responsible for tuberculosis, is one of the most
successful pathogens in human history. An extremely resilient cell wall and highly evolved …

Epigenetics in tuberculosis: immunomodulation of host immune response

A Khadela, VP Chavda, H Postwala, Y Shah, P Mistry… - Vaccines, 2022 - mdpi.com
Tuberculosis is a stern, difficult to treat chronic infection caused by acid-fast bacilli that tend
to take a long time to be eradicated from the host's environment. It requires the action of both …

MicrobeAnnotator: a user-friendly, comprehensive functional annotation pipeline for microbial genomes

CA Ruiz-Perez, RE Conrad, KT Konstantinidis - BMC bioinformatics, 2021 - Springer
Background High-throughput sequencing has increased the number of available microbial
genomes recovered from isolates, single cells, and metagenomes. Accordingly, fast and …

From gene to protein—How bacterial virulence factors manipulate host gene expression during infection

L Denzer, H Schroten, C Schwerk - International Journal of Molecular …, 2020 - mdpi.com
Bacteria evolved many strategies to survive and persist within host cells. Secretion of
bacterial effectors enables bacteria not only to enter the host cell but also to manipulate host …

The microbiota-gut-brain axis: an emerging role for the epigenome

T Louwies, AC Johnson, A Orock… - Experimental …, 2020 - journals.sagepub.com
Through the gut-brain axis, the microorganisms that reside in the gut are able to exert an
important influence on the central nervous system. Preclinical and clinical evidence …