Nucleic acid drugs have the advantages of rich target selection, simple in design, good and
enduring effect. They have been demonstrated to have irreplaceable superiority in brain …

Glioblastoma (GBM) is the most aggressive form of brain cancer, with a dismal prognosis
and extremely low percentage of survivors. Novel therapies are in dire need to improve the …

Therapeutically engineered stem cells (SC) are emerging as an effective tumor-targeted
approach for different cancer types. However, the assessment of the long-term fate of …

The attractiveness of prodrug cancer gene therapy by stem cells targeted to tumors lies in
activating the prodrug directly within the tumor mass, thus avoiding systemic toxicity. Suicide …

Human stem cells are in evaluation in clinical stem cell trials, primarily as autologous bone
marrow studies, autologous and allogenic mesenchymal stem cell trials, and some allogenic …

Purpose: Durable complete remission of metastatic renal cell carcinoma (RCC) has rarely
been achieved with current treatment modalities. To solve this problem, alternative …

Over the past decade, various enzyme/prodrug systems such as thymidine
kinase/ganciclovir (TK/GCV), yeast cytosine deaminase/5-fluorocytosine (yCD/5-FC) and …

Glioblastoma multiforme (GBM) is the most frequent and devastating primary brain tumor in
adults. Despite current treatment modalities, such as surgical resection followed by …

Background Glioblastoma multiforme (GBM) is associated with remarkably poor prognosis,
and its treatment is challenging. This investigation aimed to evaluate the safety of suicide …

Stem cell–based therapies are expected to have a great impact on the medicine of the 21st
century. The focus of dermatologic stem cell research is on the epidermis and the hair …