[HTML][HTML] Role of the CXCL8-CXCR1/2 axis in cancer and inflammatory diseases
H Ha, B Debnath, N Neamati - Theranostics, 2017 - ncbi.nlm.nih.gov
The chemokine receptors CXCR1/2 and their ligand CXCL8 are essential for the activation
and trafficking of inflammatory mediators as well as tumor progression and metastasis. The …
and trafficking of inflammatory mediators as well as tumor progression and metastasis. The …
Neutrophil migration in infection and wound repair: going forward in reverse
S De Oliveira, EE Rosowski… - Nature Reviews …, 2016 - nature.com
Neutrophil migration and its role during inflammation has been the focus of increased
interest in the past decade. Advances in live imaging and the use of new model systems …
interest in the past decade. Advances in live imaging and the use of new model systems …
The CXCL8/IL-8 chemokine family and its receptors in inflammatory diseases
Chemokines are small proteins that control several tissue functions, including cell
recruitment and activation under homeostatic and inflammatory conditions. CXCL8 …
recruitment and activation under homeostatic and inflammatory conditions. CXCL8 …
Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure
PE Marques, SS Amaral, DA Pires, LL Nogueira… - …, 2012 - Wiley Online Library
Acetaminophen (APAP) is a safe analgesic and antipyretic drug. However, APAP overdose
leads to massive hepatocyte death. Cell death during APAP toxicity occurs by oncotic …
leads to massive hepatocyte death. Cell death during APAP toxicity occurs by oncotic …
Targeting CXCR1 and CXCR2 receptors in cardiovascular diseases
CXCR1 and CXCR2 chemokine receptors, mainly activated by interleukin 8 (IL-8 or CXCL8),
are expressed in a variety of cells including, leukocytes, fibroblasts, endothelial cells, and …
are expressed in a variety of cells including, leukocytes, fibroblasts, endothelial cells, and …
Ladarixin, an inhibitor of the interleukin‐8 receptors CXCR1 and CXCR2, in new‐onset type 1 diabetes: A multicentre, randomized, double‐blind, placebo‐controlled …
L Piemonti, B Keymeulen, P Gillard… - Diabetes, Obesity …, 2022 - Wiley Online Library
Aim To evaluate the ability of ladarixin (LDX, 400 mg twice‐daily for three cycles of 14 days
on/14 days off), an inhibitor of the CXCR1/2 chemokine receptors, to maintain C‐peptide …
on/14 days off), an inhibitor of the CXCR1/2 chemokine receptors, to maintain C‐peptide …
[HTML][HTML] Cancer-associated adipocytes promote the invasion and metastasis in breast cancer through LIF/CXCLs positive feedback loop
C Zhou, X He, C Tong, H Li, C Xie, Y Wu… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Abstract Cancer-associated adipocytes (CAAs), which are adipocytes transformed by cancer
cells, are of great importance in promoting the progression of breast cancer. However, the …
cells, are of great importance in promoting the progression of breast cancer. However, the …
CXCR1/2 dual-inhibitor ladarixin reduces tumour burden and promotes immunotherapy response in pancreatic cancer
Background Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with
few therapeutic options available. Despite immunotherapy has revolutionised cancer …
few therapeutic options available. Despite immunotherapy has revolutionised cancer …
CXCR1 and CXCR2 inhibition by ladarixin improves neutrophil-dependent airway inflammation in mice
Rationale Increased IL-8 levels and neutrophil accumulation in the airways are common
features found in patients affected by pulmonary diseases such as Asthma, Idiopathic …
features found in patients affected by pulmonary diseases such as Asthma, Idiopathic …
Touch of chemokines
Chemoattractant cytokines or chemokines constitute a family of structurally related proteins
found in vertebrates, bacteria, or viruses. So far, 48 chemokine genes have been identified …
found in vertebrates, bacteria, or viruses. So far, 48 chemokine genes have been identified …