The oxidation of flavin hydroquinones by O2 in solution is slow, with second-order rate
constants of∼ 250 M–1 s–1. This is due to the obligatory, single-electron transfer that …

Human choline dehydrogenase (CHD) is located in the inner membrane of mitochondria
primarily in liver and kidney and catalyzes the oxidation of choline to glycine betaine. Its …

The choline oxidase (CHOA) and betaine aldehyde dehydrogenase (BADH) genes
identified in Aspergillus fumigatus are present as a cluster specific for fungal genomes …

Choline oxidase from Arthrobacter globiformis, which is involved in the biosynthesis of
glycine betaine from choline, has been extensively characterized in its mechanistic and …

Choline oxidase catalyzes the oxidation of choline to glycine betaine through a two-step,
four-electron reaction with betaine aldehyde as an intermediate. Oxygen is the final electron …

Choline dehydrogenase (CHDH) is a membrane-bound enzyme belonging to the glucose-
methanol-choline (GMC) oxidoreductase superfamily, which is characterized by a crucial …

Choline oxidase catalyzes the flavin-dependent, two-step oxidation of choline to glycine
betaine with the formation of an aldehyde intermediate. In the first oxidation reaction, the …

Choline oxidase serves as a paradigm for alcohol oxidation catalyzed by flavin-dependent
enzymes. In its active site, S101 is 4 Å from the flavin C4a atom on an extended loop …

Choline oxidase oxidizes choline to glycine betaine, with two flavin-mediated reactions to
convert the alcohol substrate to the carbon acid product. Proton abstraction from choline or …

The effect of temperature on the reaction of alcohol oxidation catalyzed by choline oxidase
was investigated with the S101A variant of choline oxidase. Anaerobic enzyme reduction in …