Mesenchymal stem cell mechanisms of action and clinical effects in osteoarthritis: a narrative review

V Molnar, E Pavelić, K Vrdoljak, M Čemerin, E Klarić… - Genes, 2022 - mdpi.com
With the insufficient satisfaction rates and high cost of operative treatment for osteoarthritis
(OA), alternatives have been sought. Furthermore, the inability of current medications to …

Spatial analysis of the osteoarthritis microenvironment: techniques, insights, and applications

X Fan, AR Sun, RSE Young, IO Afara, BR Hamilton… - Bone Research, 2024 - nature.com
Osteoarthritis (OA) is a debilitating degenerative disease affecting multiple joint tissues,
including cartilage, bone, synovium, and adipose tissues. OA presents diverse clinical …

An adolescent murine in vivo anterior cruciate ligament overuse injury model

BE Loflin, T Ahn, KA Colglazier… - … American Journal of …, 2023 - journals.sagepub.com
Background: Overuse ligament and tendon injuries are prevalent among recreational and
competitive adolescent athletes. In vitro studies of the ligament and tendon suggest that …

[HTML][HTML] Effectiveness of losartan on infrapatellar fat pad/synovial fibrosis and pain behavior in the monoiodoacetate-induced rat model of osteoarthritis pain

O Sriwatananukulkit, S Desclaux… - Biomedicine & …, 2023 - Elsevier
Infrapatellar fat pad (IFP)/synovial fibrosis is closely associated with the clinical symptoms of
joint pain and stiffness, which contribute to locomotor restriction in osteoarthritis (OA) …

Healthy and osteoarthritis-affected joints facing the cellular crosstalk

S Semenistaja, S Skuja, A Kadisa, V Groma - International Journal of …, 2023 - mdpi.com
Osteoarthritis (OA) is a chronic, progressive, severely debilitating, and multifactorial joint
disease that is recognized as the most common type of arthritis. During the last decade, it …

Acute bone loss and infrapatellar fat pad fibrosis in the knee after an in vivo ACL injury in adolescent mice

T Ahn, BE Loflin, NB Nguyen… - … American Journal of …, 2023 - journals.sagepub.com
Background: Young patients are 6 times more likely than adults to have a primary anterior
cruciate ligament (ACL) graft failure. Biological factors (ie, tunnel osteolysis) may account for …

Cross-communication between knee osteoarthritis and fibrosis: molecular pathways and key molecules

IK Bolia, K Mertz, E Faye, J Sheppard… - Open Access Journal …, 2022 - Taylor & Francis
Knee fibrosis is characterized by the presence of excessive connective tissue due to
dysregulated fibroblast activation following local or systemic tissue damage. Knee fibrosis …

The impact of digital healthcare systems on pain and body function in patients with knee joint pain: a systematic review and meta-analysis

L Guo, S Li, S Xie, L Bian, S Shaharudin - Scientific reports, 2024 - nature.com
The digital healthcare (DH) system has recently emerged as an advanced rehabilitation
approach that promotes rehabilitation training based on virtual reality (VR) and augmented …

Histologic and molecular features in pathologic human menisci from knees with and without osteoarthritis

FA Monibi, T Pannellini, M Otero… - Journal of …, 2022 - Wiley Online Library
The objective of this study was to evaluate histologic and molecular features of meniscus
degeneration in cohorts of patients with and without osteoarthritis (OA) of the knee. Menisci …

Targeted transcriptomic analyses of RNA isolated from formalin‐fixed and paraffin‐embedded human menisci

FA Monibi, T Pannellini, B Croen… - Journal of …, 2022 - Wiley Online Library
Formalin‐fixed and paraffin‐embedded (FFPE) biospecimens are a valuable and widely‐
available resource for diagnostic and research applications. With biobanks of tissue …