Covering: 2010 to 2022 Heterologous expression of natural product biosynthetic gene
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …

The discovery of new enzymes, alongside the push to make chemical processes more
sustainable, has resulted in increased industrial interest in the use of biocatalytic processes …

The construction of O-heterocycles is an important step in organic synthesis and
biosynthesis for producing valuable ring compounds. Although enzyme-catalysed five-or six …

Abstract Tandem Diels–Alder reactions are frequently used in the construction of polycyclic
ring systems in complex organic compounds. Unlike the many Diels− Alderases (DAases) …

Abstract Natural Diels–Alderases that selectively form endo or exo products are increasingly
well known but generally form one stereoisomer with limited substrate scope. Here we report …

Cycloaddition reactions are among the most widely used reactions in chemical synthesis.
Nature achieves these cyclization reactions with a variety of enzymes, including Diels …

New-to-nature radical biocatalysis has recently emerged as a powerful strategy to tame
fleeting open-shell intermediates for stereoselective transformations. In 2021, we introduced …

The rapid and precise creation of complex molecules while controlling multiple selectivities
is the principal objective in synthetic chemistry. Combining data science and organic …

Recent advances in the development of reactive machine-learned potentials (MLPs)
promise to transform reaction modelling. However, such methods have remained …

Stereoselective synthesis of cis-decalin structures using [4+ 2] cycloaddition is challenging.
We explored the biosynthetic pathway of the fungal natural product fischerin (1) to identify a …