Molecular mechanisms of CRISPR-Cas immunity in bacteria
PM Nussenzweig, LA Marraffini - Annual review of genetics, 2020 - annualreviews.org
Prokaryotes have developed numerous defense strategies to combat the constant threat
posed by the diverse genetic parasites that endanger them. Clustered regularly interspaced …
posed by the diverse genetic parasites that endanger them. Clustered regularly interspaced …
Evolutionary plasticity and functional versatility of CRISPR systems
EV Koonin, KS Makarova - PLoS Biology, 2022 - journals.plos.org
The principal biological function of bacterial and archaeal CRISPR systems is RNA-guided
adaptive immunity against viruses and other mobile genetic elements (MGEs). These …
adaptive immunity against viruses and other mobile genetic elements (MGEs). These …
Uncovering the functional diversity of rare CRISPR-Cas systems with deep terascale clustering
Microbial systems underpin many biotechnologies, including CRISPR, but the exponential
growth of sequence databases makes it difficult to find previously unidentified systems. In …
growth of sequence databases makes it difficult to find previously unidentified systems. In …
Alternative functions of CRISPR–Cas systems in the evolutionary arms race
CRISPR–Cas systems of bacteria and archaea comprise chromosomal loci with typical
repetitive clusters and associated genes encoding a range of Cas proteins. Adaptation of …
repetitive clusters and associated genes encoding a range of Cas proteins. Adaptation of …
CRISPR-Cas systems are widespread accessory elements across bacterial and archaeal plasmids
R Pinilla-Redondo, J Russel… - Nucleic acids …, 2022 - academic.oup.com
Many prokaryotes encode CRISPR-Cas systems as immune protection against mobile
genetic elements (MGEs), yet a number of MGEs also harbor CRISPR-Cas components …
genetic elements (MGEs), yet a number of MGEs also harbor CRISPR-Cas components …
The CRISPR-Cas mechanism for adaptive immunity and alternate bacterial functions fuels diverse biotechnologies
S Newsom, HP Parameshwaran, L Martin… - Frontiers in cellular and …, 2021 - frontiersin.org
Bacterial and archaeal CRISPR-Cas systems offer adaptive immune protection against
foreign mobile genetic elements (MGEs). This function is regulated by sequence specific …
foreign mobile genetic elements (MGEs). This function is regulated by sequence specific …
Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation
Among the multiple antiviral defense mechanisms found in prokaryotes, CRISPR-Cas
systems stand out as the only known RNA-programmed pathways for detecting and …
systems stand out as the only known RNA-programmed pathways for detecting and …
Endogenous type I CRISPR-Cas: from foreign DNA defense to prokaryotic engineering
Y Zheng, J Li, B Wang, J Han, Y Hao… - … in bioengineering and …, 2020 - frontiersin.org
Establishment of production platforms through prokaryotic engineering in microbial
organisms would be one of the most efficient means for chemicals, protein, and biofuels …
organisms would be one of the most efficient means for chemicals, protein, and biofuels …
Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment
N Cui, JT Zhang, Y Liu, Y Liu, XY Liu, C Wang… - Molecular Cell, 2023 - cell.com
Summary Type IV CRISPR-Cas systems, which are primarily found on plasmids and exhibit
a strong plasmid-targeting preference, are the only one of the six known CRISPR-Cas types …
a strong plasmid-targeting preference, are the only one of the six known CRISPR-Cas types …
Genome-wide CRISPR screen identifies genes synthetically lethal with GRA17, a nutrient channel encoding gene in Toxoplasma
Toxoplasma gondii is a parasite that replicates within a specialized compartment called the
parasitophorous vacuole (PV), which is surrounded by the PV membrane (PVM). To obtain …
parasitophorous vacuole (PV), which is surrounded by the PV membrane (PVM). To obtain …