Advances in copper complexes as anticancer agents
Medicinal inorganic chemistry offers additional opportunities for the design of therapeutic
agents not accessible to organic compounds. 1− 3 The wide range of coordination numbers …
agents not accessible to organic compounds. 1− 3 The wide range of coordination numbers …
Copper, gold and silver compounds as potential new anti-tumor metallodrugs
Although platinum-based drugs such as cisplatin are powerful anticancer agents, they have
undesirable side effects and are effective against only a few kinds of cancers. There is …
undesirable side effects and are effective against only a few kinds of cancers. There is …
Effect of N (4)-phenyl substitution in 2-oxo-1, 2-dihydroquinoline-3-carbaldehyde semicarbazones on the structure, DNA/protein interaction, and antioxidative and …
D Senthil Raja, NSP Bhuvanesh… - Inorganic Chemistry, 2011 - ACS Publications
A new ligand, 2-oxo-1, 2-dihydroquinoline-3-carbaldehyde semicarbazone (OQsc-H)(1);, its
N (4)-phenyl derivative (OQsc-Ph)(2); and their corresponding copper (II) complexes [CuCl2 …
N (4)-phenyl derivative (OQsc-Ph)(2); and their corresponding copper (II) complexes [CuCl2 …
Copper complexes based on chiral Schiff-base ligands: DNA/BSA binding ability, DNA cleavage activity, cytotoxicity and mechanism of apoptosis
Four copper (II) complexes with chiral Schiff-base ligands,[Cu (RL 1) 2]· EtOAc (1) and [Cu
(SL 1) 2]· EtOAc (2),[Cu (RL 2) 2]· EtOAc (3) and [Cu (SL 2) 2]· EtOAc (4),(R/S-HL 1=(R/S)-(1 …
(SL 1) 2]· EtOAc (2),[Cu (RL 2) 2]· EtOAc (3) and [Cu (SL 2) 2]· EtOAc (4),(R/S-HL 1=(R/S)-(1 …
Copper (II) complexes with tridentate halogen-substituted Schiff base ligands: synthesis, crystal structures and investigating the effect of halogenation, leaving groups …
To investigate the effect of different halogen substituents and leaving groups and the
flexibility of ligands on the anticancer activity of copper complexes, sixteen copper (II) …
flexibility of ligands on the anticancer activity of copper complexes, sixteen copper (II) …
Copper (II) complexes based on thiosemicarbazone ligand: Preparation, crystal structure, Hirshfeld surface, energy framework, antiMycobacterium activity, in silico …
RAC Souza, WRP Costa, EF Faria, MAS Bessa… - Journal of Inorganic …, 2021 - Elsevier
Considering the promising previous results on the remarkable activity exhibited by cobalt (III)
and manganese (II) thiosemicarbazone compounds as antibacterial agents, the present …
and manganese (II) thiosemicarbazone compounds as antibacterial agents, the present …
l- and d-Proline Thiosemicarbazone Conjugates: Coordination Behavior in Solution and the Effect of Copper(II) Coordination on Their Antiproliferative Activity
MNM Milunovic, ÉA Enyedy, NV Nagy, T Kiss… - Inorganic …, 2012 - ACS Publications
Two enantiomerically pure thiosemicarbazone–proline conjugates with enhanced aqueous
solubility, namely, 2-hydroxy-3-methyl-(S)-pyrrolidine-2-carboxylate-5-methylbenzaldehyde …
solubility, namely, 2-hydroxy-3-methyl-(S)-pyrrolidine-2-carboxylate-5-methylbenzaldehyde …
Synthesis, characterization and cytotoxic activity of novel copper (II) complexes with aroylhydrazone derivatives of 2-Oxo-1, 2-dihydrobenzo [h] quinoline-3 …
E Ramachandran, V Gandin, R Bertani… - Journal of inorganic …, 2018 - Elsevier
Abstract Three new 2-oxo-1, 2-dihydrobenzo [h] quinoline-3-carbaldehyde terminal
substituted aroylhydrazone ligands (2-Oxo-1, 2-dihydrobenzo [h] quinoline-3-carbaldehyde …
substituted aroylhydrazone ligands (2-Oxo-1, 2-dihydrobenzo [h] quinoline-3-carbaldehyde …
Novel chelators based on adamantane-derived semicarbazones and hydrazones that target multiple hallmarks of Alzheimer's disease
D Palanimuthu, Z Wu, PJ Jansson, N Braidy… - Dalton …, 2018 - pubs.rsc.org
Alzheimer's disease (AD) is characterized by multiple pathological hallmarks, including β-
amyloid aggregation, oxidative stress, and metal dys-homeostasis. In the absence of …
amyloid aggregation, oxidative stress, and metal dys-homeostasis. In the absence of …
Investigation of Structures, QTAIM, RDG, ADMET, and docking properties of SASC compound using experimental and theoretical approach
N Kavitha, M Alivelu - Computational and Theoretical Chemistry, 2021 - Elsevier
In this work, the FT-IR spectra of synthesized molecule Salicilaldehyde Semicarbazone
(SASC) was characterized by using density functional theory (DFT) with B3LYP/6–311++ G …
(SASC) was characterized by using density functional theory (DFT) with B3LYP/6–311++ G …