Schizophrenia is a chronic and debilitating neuropsychiatric disorder affecting
approximately 1% of the world's population. This disease is associated with considerable …

Piperazine and homopiperazine are well-studied heterocycles in drug design that have
found gainful application as scaffolds and terminal elements and for enhancing the aqueous …

Background The concept of molecular similarity is one of the central ideas in
cheminformatics, despite the fact that it is ill-defined and rather difficult to assess objectively …

G-protein–coupled receptors (GPCRs) still offer enormous scope for new therapeutic targets.
Currently marketed agents are dominated by those with activity at aminergic receptors and …

Dopamine is a biologically active amine synthesized in the central and peripheral nervous
system. This biogenic monoamine acts by activating five types of dopamine receptors (D1 …

Background For psychotic disorders (ie schizophrenia), pharmacotherapy plays a key role in
controlling acute and long-term symptoms. To find the optimal individual dose and dosage …

Piperidine and piperazine derivatives exhibit a diverse range of biological applications,
including antipsychotic activity. In this study, a dataset of molecules containing piperidine …

Neurodegenerative diseases, such as Alzheimer's disease or Parkinson's disease,
significantly reduce the quality of life of patients and eventually result in complete …

Diseases of the central nervous system are an alarming global problem showing an
increasing prevalence. Dopamine receptor D2 (D2R) has been shown to be involved in …

Abstract The cannabinoid type 1 (CB1) receptor and the dopamine type 2 (D2) receptor are
co‐localized on medium spiny neuron terminals in the globus pallidus where they modulate …