We describe new tools for the processing of electron cryo-microscopy (cryo-EM) images in
the fourth major release of the RELION software. In particular, we introduce VDAM, a …

The three-dimensional positions of atoms in protein molecules define their structure and
their roles in biological processes. The more precisely atomic coordinates are determined …

Traditionally, X-ray crystallography and NMR spectroscopy represent major workhorses of
structural biologists, with the lion share of protein structures reported in protein data bank …

INTRODUCTION In eukaryotic cells, the selective bidirectional transport of macromolecules
between the nucleus and cytoplasm occurs through the nuclear pore complex (NPC) …

Nicotinamide adenine dinucleotide (NAD+) is a central metabolite in cellular processes.
Depletion of NAD+ has been demonstrated to be a prevalent theme in both prokaryotic and …

With conformation-specific nanobodies being used for a wide range of structural,
biochemical, and cell biological applications, there is a demand for antigen-binding …

Biological macromolecules and assemblies precisely rearrange their atomic 3D structures to
execute cellular functions. Understanding the mechanisms by which these molecular …

DNA can be folded into rationally designed, unique, and functional materials. To fully realise
the potential of these DNA materials, a fundamental understanding of their structure and …

Cryptophyte plastids originated from a red algal ancestor through secondary endosymbiosis.
Cryptophyte photosystem I (PSI) associates with transmembrane alloxanthin-chlorophyll a/c …

Human ABC transporter ABCD1 transports very long-chain fatty acids from cytosol to
peroxisome for β-oxidation, dysfunction of which usually causes the X-linked …