Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …

Short tandem repeat (STR) or microsatellite, expansions underlie more than 50 hereditary
neurological, neuromuscular and other diseases, including myotonic dystrophy types 1 …

Muscleblind (mbl) is an essential muscle and neuronal splicing regulator. Mbl hosts multiple
circular RNAs (circRNAs), including circMbl, which is conserved from flies to humans. Here …

Dysregulation of pre-mRNA splicing is a common hallmark of cancer cells and it is
associated with altered expression, localization, and mutations of the components of the …

As part of the superfamily of long noncoding RNAs, circular RNAs (circRNAs) are emerging
as a new type of regulatory molecules that partake in gene expression control. Here, we …

Muscleblind-like (MBNL) proteins bind to hundreds of pre-and mature mRNAs to regulate
their alternative splicing, alternative polyadenylation, stability and subcellular localization …

Muscleblind-like (MBNL) proteins are conserved RNA-binding factors involved in alternative
splicing (AS) regulation during development. While AS is controlled by distribution of MBNL …

Circular RNAs (circRNAs) constitute a recently re-discovered class of non-coding RNAs
functioning as sponges for miRNAs and proteins, affecting RNA splicing and regulating …

Alternative splicing of genes in the central nervous system is ubiquitous and utilizes many
different mechanisms. Splicing generates unique transcript or protein isoforms of the primary …

Brain dysfunction in myotonic dystrophy type 1 (DM1), the prototype of toxic RNA disorders,
has been mainly attributed to neuronal RNA misprocessing, while little attention has been …