The ambient humidity varies with seasons and geographical altitude across the regions. A
change in relative humidity during processing, storage, and transportation can cause …

Pharmaceutical cocrystals and salts are extensively researched in recent years due to their
ability to tune the physicochemical properties of active pharmaceutical ingredients (APIs). A …

Berberine chloride (BCl) can exist as an anhydrate, monohydrate, dihydrate, and
tetrahydrate. Therefore, it faces the problem of humidity dependent solid phase change …

Pharmaceutical salt formation is the most preferred and effective method to enhance the
physicochemical properties of an active pharmaceutical ingredient (API) such as solubility …

Pirfenidone (PFD) is the first pharmacological agent approved by the US Food and Drug
Administration (FDA) in 2014 for the treatment of idiopathic pulmonary fibrosis (IPF). The …

Pirfenidone is an important drug molecule used in the treatment of idiopathic lung fibrosis.
Although approved by the USFDA in 2014, pirfenidone's aqueous solubility is too high and …

Multidrug salts represent more than one drug in a crystal lattice and thus could be used to
deliver multiple drugs in a single dose. It showcases unique physicochemical properties in …

In this study, we attempted to synthesize drug–drug multicomponent crystals containing
epalrestat (EP) and metformin (MET)(two drugs both used for diabetes treatment) to improve …

Drug–drug and drug–nutraceutical multicomponent solids of an antipsychotic drug
olanzapine (OLN) are prepared using mechanochemistry. Drug molecules, viz., nateglinide …

Olanzapine (OLN), an antipsychotic drug, is one of the most widely studied pharmaceutical
materials. Although OLN and most of their multicomponent solids are highly crystalline …