Natural source, bioactivity and synthesis of benzofuran derivatives
Y Miao, Y Hu, J Yang, T Liu, J Sun, X Wang - RSC advances, 2019 - pubs.rsc.org
Benzofuran compounds are a class of compounds that are ubiquitous in nature. Numerous
studies have shown that most benzofuran compounds have strong biological activities such …
studies have shown that most benzofuran compounds have strong biological activities such …
Alzheimer's disease: updated multi-targets therapeutics are in clinical and in progress
Z Sang, K Wang, J Dong, L Tang - European journal of medicinal chemistry, 2022 - Elsevier
Alzheimer's disease is a chronic and progressive brain neurodegenerative disease affecting
over 30 million people globally. Currently, no effective treatment is available due to multiple …
over 30 million people globally. Currently, no effective treatment is available due to multiple …
Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease
Q Li, H Yang, Y Chen, H Sun - European journal of medicinal chemistry, 2017 - Elsevier
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders with
notable factor of dysfunction in cholinergic system. Low ACh level can be observed in the …
notable factor of dysfunction in cholinergic system. Low ACh level can be observed in the …
Multi-target design strategies for the improved treatment of Alzheimer's disease
P Zhang, S Xu, Z Zhu, J Xu - European journal of medicinal chemistry, 2019 - Elsevier
Alzheimer's disease (AD) is a multifactorial syndrome resulting in profound misery and
poses a substantial burden on human health, economy, and society throughout the world …
poses a substantial burden on human health, economy, and society throughout the world …
Structural Modification, In Vitro, In Vivo, Ex Vivo, and In Silico Exploration of Pyrimidine and Pyrrolidine Cores for Targeting Enzymes Associated with …
MA Javed, N Ashraf, M Saeed Jan… - ACS Chemical …, 2021 - ACS Publications
To obtain a multipotent framework that can target simultaneously COX-2, 5-LOX,
acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) to treat neuroinflammation …
acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) to treat neuroinflammation …
A review on antioxidant potential of bioactive heterocycle benzofuran: Natural and synthetic derivatives
K Chand, A Hiremathad, M Singh, MA Santos… - Pharmacological …, 2017 - Elsevier
The majority of heterocycle compounds and typically common heterocycle fragments
present in most pharmaceuticals currently marketed, alongside with their intrinsic versatility …
present in most pharmaceuticals currently marketed, alongside with their intrinsic versatility …
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998–2018)
Alzheimer's disease (AD) is a genetically complex, progressive and irreversible
neurodegenerative disorder of the brain which involves multiple associated etiological …
neurodegenerative disorder of the brain which involves multiple associated etiological …
The magic of crystal structure-based inhibitor optimization: development of a butyrylcholinesterase inhibitor with picomolar affinity and in vivo activity
U Kosak, B Brus, D Knez, S Zakelj… - Journal of medicinal …, 2018 - ACS Publications
The enzymatic activity of butyrylcholinesterase (BChE) in the brain increases with the
progression of Alzheimer's disease, thus classifying BChE as a promising drug target in …
progression of Alzheimer's disease, thus classifying BChE as a promising drug target in …
Multifactorial hypothesis and multi-targets for Alzheimer's disease
The amyloid cascade hypothesis has been dominating drug discovery for Alzheimer's
disease (AD) for the last two decades. The failure of the development of effective drugs for …
disease (AD) for the last two decades. The failure of the development of effective drugs for …
Benzofuran and indole: promising scaffolds for drug development in Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disease with no clinically
accepted treatment to cure or halt its progression. The Food and Drug Administration has …
accepted treatment to cure or halt its progression. The Food and Drug Administration has …