Stem cell transplantation holds great promise as a potential treatment for currently incurable
retinal degenerative diseases that cause poor vision and blindness. Recently, safety data …

Due to improved phenotyping and genetic characterization, the field of 'incurable'and
'blinding'inherited retinal diseases (IRDs) has moved substantially forward. Decades of …

Lipofuscin granules enclose mixtures of cross-linked proteins and lipids in proportions that
depend on the tissue analyzed. Retinal lipofuscin is unique in that it contains mostly lipids …

The methyl-d3 group is a new isotopic functional group for medicine design. In this work, we
report an electrochemical deuteration approach for converting aromatic trifluoromethyl to …

Stargardt disease (STGD1) and ABCA4 retinopathies (ABCA4R) are caused by pathogenic
variants in the ABCA4 gene inherited in an autosomal recessive manner. The gene encodes …

Despite considerable effort and significant therapeutic advances, age-related macular
degeneration (AMD) remains the commonest cause of blindness in the developed world …

Importance Sensitive outcome measures for disease progression are needed for treatment
trials of Stargardt disease. Objective To estimate the progression rate of atrophic lesions in …

Age-related macular degeneration, Stargardt disease, and their Abca4-/-mouse model are
characterized by accelerated accumulation of the pigment lipofuscin, derived from …

Stargardt disease (STGD1) is an autosomal recessive retinal dystrophy, characterised by
bilateral progressive central vision loss and subretinal deposition of lipofuscin‐like …

Accumulation of bisretinoids such as A2E and its isomer iso-A2E is thought to mediate blue
light-induced oxidative damage associated with age-related macular degeneration (AMD) …