Liver regeneration has been studied for many decades and the mechanisms underlying
regeneration of the normal liver following resection or moderate damage are well described …

As the incidence of hepatobiliary diseases increases, we must improve our understanding of
the molecular, cellular, and physiological factors that contribute to the pathogenesis of liver …

Cytosine DNA methylation is a heritable epigenetic mark present in many eukaryotic
organisms. Although DNA methylation likely has a conserved role in gene silencing, the …

Tissue damage can resolve completely through healing and regeneration, or can produce
permanent scarring and loss of function. The response to tissue damage varies across …

Hepatocytes, like other epithelia, are situated at the interface between the organism's
exterior and the underlying internal milieu and organize the vectorial exchange of …

Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is an essential regulator of
DNA methylation that is highly expressed in many cancers. Here, we use transgenic …

The liver is unique in its ability to regenerate in response to injury. A number of evolutionary
safeguards have allowed the liver to continue to perform its complex functions despite …

Ablation studies are used to elucidate cell lineage relationships, developmental roles for
specific cells during embryogenesis and mechanisms of tissue regeneration. Previous …

The intestinal epithelium forms a barrier protecting the organism from microbes and other
proinflammatory stimuli. The integrity of this barrier and the proper response to infection …

The liver is a highly regenerative organ, but its regenerative capacity is compromised in
severe liver diseases. Hepatocyte-driven liver regeneration that involves the proliferation of …