Advanced liposome and polymersome-based drug delivery systems: Considerations for physicochemical properties, targeting strategies and stimuli-sensitive …
Liposomes and polymersomes are colloidal vesicles that are self-assembled from lipids and
amphiphilic polymers, respectively. Because of their ability to encapsulate both hydrophilic …
amphiphilic polymers, respectively. Because of their ability to encapsulate both hydrophilic …
[HTML][HTML] Molecular targets of cannabidiol in neurological disorders
Cannabis has a long history of anecdotal medicinal use and limited licensed medicinal use.
Until recently, alleged clinical effects from anecdotal reports and the use of licensed …
Until recently, alleged clinical effects from anecdotal reports and the use of licensed …
Insulin resistance and Alzheimer's disease: bioenergetic linkages
BJ Neth, S Craft - Frontiers in aging neuroscience, 2017 - frontiersin.org
Metabolic dysfunction is a well-established feature of Alzheimer's disease (AD), evidenced
by brain glucose hypometabolism that can be observed potentially decades prior to the …
by brain glucose hypometabolism that can be observed potentially decades prior to the …
Cytosolic phospholipase A2: physiological function and role in disease
CC Leslie - Journal of lipid research, 2015 - ASBMB
The group IV phospholipase A 2 (PLA 2) family is comprised of six intracellular enzymes
(GIVA,-B,-C,-D,-E, and-F) commonly referred to as cytosolic PLA 2 (cPLA 2) α,-β,-γ,-δ,-ε, and …
(GIVA,-B,-C,-D,-E, and-F) commonly referred to as cytosolic PLA 2 (cPLA 2) α,-β,-γ,-δ,-ε, and …
Consequences of oxidative stress in age-related macular degeneration
SG Jarrett, ME Boulton - Molecular aspects of medicine, 2012 - Elsevier
The retina resides in an environment that is primed for the generation of reactive oxygen
species (ROS) and resultant oxidative damage. The retina is one of the highest oxygen …
species (ROS) and resultant oxidative damage. The retina is one of the highest oxygen …
Stimulus-responsive liposomes for biomedical applications
AI Antoniou, S Giofrè, P Seneci, D Passarella… - Drug discovery today, 2021 - Elsevier
Liposomes are amphipathic lipidic supramolecular aggregates that are able to encapsulate
and carry molecules of both hydrophilic and hydrophobic nature. They have been widely …
and carry molecules of both hydrophilic and hydrophobic nature. They have been widely …
[HTML][HTML] Brain docosahexaenoic acid uptake and metabolism
RJS Lacombe, R Chouinard-Watkins… - Molecular Aspects of …, 2018 - Elsevier
Docosahexaenoic acid (DHA) is the most abundant n-3 polyunsaturated fatty acid in the
brain where it serves to regulate several important processes and, in addition, serves as a …
brain where it serves to regulate several important processes and, in addition, serves as a …
Identification of pathways for bipolar disorder: a meta-analysis
Importance Genome-wide investigations provide systematic information regarding the
neurobiology of psychiatric disorders. Objective To identify biological pathways that …
neurobiology of psychiatric disorders. Objective To identify biological pathways that …
Focus on the glycerophosphocholine pathway in choline phospholipid metabolism of cancer
Activated choline metabolism is a hallmark of carcinogenesis and tumor progression, which
leads to elevated levels of phosphocholine and glycerophosphocholine in all types of …
leads to elevated levels of phosphocholine and glycerophosphocholine in all types of …
Kaempferol alleviates LPS-induced neuroinflammation and BBB dysfunction in mice via inhibiting HMGB1 release and down-regulating TLR4/MyD88 pathway
X Cheng, YL Yang, H Yang, YH Wang… - International …, 2018 - Elsevier
Kaempferol is a natural flavonoid with many biological activities including anti-oxidation and
anti-inflammation. Nevertheless, its anti-neuroinflammation role and the relevant mechanism …
anti-inflammation. Nevertheless, its anti-neuroinflammation role and the relevant mechanism …