Metastases arise from residual disseminated tumour cells (DTCs). This can happen years
after primary tumour treatment because residual tumour cells can enter dormancy and …

New and provocative insights into the relationships between iron and cancer have been
uncovered in recent years. These include delineation of connections that link cellular iron to …

Melanoma has markedly increased worldwide during the past several decades in the
Caucasian population and is responsible for 80% of skin cancer deaths. Considering that …

Significance: During the past decades, thiosemicarbazones were clinically developed for a
variety of diseases, including tuberculosis, viral infections, malaria, and cancer. With regard …

Iron plays an essential role in normal biological processes: The generation of cellular
energy, oxygen transport, DNA synthesis and repair are all processes that require iron …

As the di-2-pyridylketone thiosemicarbazone (DpT) and 2-acetylpyridine thiosemicarbazone
(ApT) series show potent antitumor activity in vitro and in vivo, we synthesized their …

Copper homeostasis is tightly regulated in both prokaryotic and eukaryotic cells to ensure
sufficient amounts for cuproprotein biosynthesis, while limiting oxidative stress production …

Significance: Under normal circumstances, cellular iron levels are tightly regulated due to
the potential toxic effects of this metal ion. There is evidence that tumors possess altered iron …

Newer and more potent therapies are urgently needed to effectively treat advanced cancers
that have developed resistance and metastasized. One such strategy is to target cancer cell …

We developed a series of second-generation di-2-pyridyl ketone thiosemicarbazone (DpT)
and 2-benzoylpyridine thiosemicarbazone (BpT) ligands to improve the efficacy and safety …