[HTML][HTML] Animal models of major depression: drawbacks and challenges
Major depression is a leading contributor to the global burden of disease. This situation is
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …
[HTML][HTML] Stress-induced plasticity and functioning of ventral tegmental dopamine neurons
EH Douma, ER de Kloet - Neuroscience & Biobehavioral Reviews, 2020 - Elsevier
The ventral tegmental area dopamine (VTA-DA) mesolimbic circuit processes emotional,
motivational, and social reward associations together with their more demanding cognitive …
motivational, and social reward associations together with their more demanding cognitive …
[HTML][HTML] Coping with the forced swim stressor: Current state-of-the-art
ML Molendijk, ER de Kloet - Behavioural brain research, 2019 - Elsevier
The forced swim test (FST) for rodents does not model despair or helplessness. It also is not
a read-out for depression, anxiety, psychomotor retardation or autism, because these are …
a read-out for depression, anxiety, psychomotor retardation or autism, because these are …
[HTML][HTML] Importance of the brain corticosteroid receptor balance in metaplasticity, cognitive performance and neuro-inflammation
ER De Kloet, OC Meijer, AF de Nicola… - Frontiers in …, 2018 - Elsevier
Bruce McEwen's discovery of receptors for corticosterone in the rat hippocampus introduced
higher brain circuits in the neuroendocrinology of stress. Subsequently, these receptors …
higher brain circuits in the neuroendocrinology of stress. Subsequently, these receptors …
Neural basis for fasting activation of the hypothalamic–pituitary–adrenal axis
Fasting initiates a multitude of adaptations to allow survival. Activation of the hypothalamic–
pituitary–adrenal (HPA) axis and subsequent release of glucocorticoid hormones is a key …
pituitary–adrenal (HPA) axis and subsequent release of glucocorticoid hormones is a key …
Top‐down and bottom‐up control of stress‐coping
ER de Kloet, SF de Kloet, CS de Kloet… - Journal of …, 2019 - Wiley Online Library
In this 30th anniversary issue review, we focus on the glucocorticoid modulation of limbic‐
prefrontocortical circuitry during stress‐coping. This action of the stress hormone is mediated …
prefrontocortical circuitry during stress‐coping. This action of the stress hormone is mediated …
Glutamatergic and GABAergic anteroventral BNST projections to PVN CRH neurons regulate maternal separation-induced visceral pain
ST Huang, K Wu, MM Guo, S Shao, R Hua… - …, 2023 - nature.com
Early-life stress (ELS) is thought to cause the development of visceral pain disorders. While
some individuals are vulnerable to visceral pain, others are resilient, but the intrinsic circuit …
some individuals are vulnerable to visceral pain, others are resilient, but the intrinsic circuit …
[HTML][HTML] What the hippocampus tells the HPA axis: Hippocampal output attenuates acute stress responses via disynaptic inhibition of CRF+ PVN neurons
The hippocampus exerts inhibitory feedback on the release of glucocorticoids. Because the
major hippocampal efferent projections are excitatory, it has been hypothesized that this …
major hippocampal efferent projections are excitatory, it has been hypothesized that this …
Forced swim stressor: Trends in usage and mechanistic consideration
ML Molendijk, ER de Kloet - European Journal of Neuroscience, 2022 - Wiley Online Library
The acquired immobility response during the “forced swim test (FST)” is not a rodent model
of depression, but the test has some validity in predicting a compound's antidepressant …
of depression, but the test has some validity in predicting a compound's antidepressant …
Wiring the depressed brain: optogenetic and chemogenetic circuit interrogation in animal models of depression
The advent of optogenetics and chemogenetics has revolutionized the study of neural circuit
mechanisms of behavioral dysregulation in psychiatric disease. These powerful …
mechanisms of behavioral dysregulation in psychiatric disease. These powerful …