Mitotic spindle assembly in animal cells: a fine balancing act

SL Prosser, L Pelletier - Nature Reviews Molecular Cell Biology, 2017 - nature.com
The mitotic spindle has a crucial role in ensuring the accurate segregation of chromosomes
into the two daughter cells during cell division, which is paramount for maintaining genome …

Microtubule nucleation: beyond the template

J Roostalu, T Surrey - Nature Reviews Molecular Cell Biology, 2017 - nature.com
Microtubules are cytoskeletal filaments central to a wide range of essential cellular functions
in eukaryotic cells. Consequently, cells need to exert tight control over when, where and how …

Microtubule-organizing centers

J Wu, A Akhmanova - Annual review of cell and developmental …, 2017 - annualreviews.org
The organization of microtubule networks is crucial for controlling chromosome segregation
during cell division, for positioning and transport of different organelles, and for cell polarity …

Mechanisms of mitotic spindle assembly

S Petry - Annual review of biochemistry, 2016 - annualreviews.org
Life depends on cell proliferation and the accurate segregation of chromosomes, which are
mediated by the microtubule (MT)-based mitotic spindle and∼ 200 essential MT-associated …

Mechanisms underlying spindle assembly and robustness

VA Valdez, L Neahring, S Petry… - Nature Reviews Molecular …, 2023 - nature.com
The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …

Asymmetric molecular architecture of the human γ-tubulin ring complex

M Wieczorek, L Urnavicius, SC Ti, KR Molloy, BT Chait… - Cell, 2020 - cell.com
The γ-tubulin ring complex (γ-TuRC) is an essential regulator of centrosomal and
acentrosomal microtubule formation, yet its structure is not known. Here, we present a cryo …

Microtubule minus-end-targeting proteins

A Akhmanova, CC Hoogenraad - Current Biology, 2015 - cell.com
Microtubules are cytoskeletal filaments that are intrinsically polarized, with two structurally
and functionally distinct ends, the plus end and the minus end. Over the last decade …

Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity

C Sánchez-Huertas, F Freixo, R Viais, C Lacasa… - Nature …, 2016 - nature.com
Neurons display a highly polarized microtubule network that mediates trafficking throughout
the extensive cytoplasm and is crucial for neuronal differentiation and function. In newborn …

Microtubule nucleation at the centrosome and beyond

S Petry, RD Vale - Nature cell biology, 2015 - nature.com
Microtubule nucleation at the centrosome and beyond | Nature Cell Biology Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited support …

Microtubule nucleation: The waltz between γ-tubulin ring complex and associated proteins

P Liu, M Würtz, E Zupa, S Pfeffer, E Schiebel - Current opinion in cell …, 2021 - Elsevier
Microtubules are essential cytoskeletal elements assembled from αβ-tubulin dimers. In high
eukaryotes, microtubule nucleation, the de novo assembly of a microtubule from its minus …