Mitotic spindle assembly in animal cells: a fine balancing act
SL Prosser, L Pelletier - Nature Reviews Molecular Cell Biology, 2017 - nature.com
The mitotic spindle has a crucial role in ensuring the accurate segregation of chromosomes
into the two daughter cells during cell division, which is paramount for maintaining genome …
into the two daughter cells during cell division, which is paramount for maintaining genome …
Microtubule nucleation: beyond the template
J Roostalu, T Surrey - Nature Reviews Molecular Cell Biology, 2017 - nature.com
Microtubules are cytoskeletal filaments central to a wide range of essential cellular functions
in eukaryotic cells. Consequently, cells need to exert tight control over when, where and how …
in eukaryotic cells. Consequently, cells need to exert tight control over when, where and how …
Microtubule-organizing centers
J Wu, A Akhmanova - Annual review of cell and developmental …, 2017 - annualreviews.org
The organization of microtubule networks is crucial for controlling chromosome segregation
during cell division, for positioning and transport of different organelles, and for cell polarity …
during cell division, for positioning and transport of different organelles, and for cell polarity …
Mechanisms of mitotic spindle assembly
S Petry - Annual review of biochemistry, 2016 - annualreviews.org
Life depends on cell proliferation and the accurate segregation of chromosomes, which are
mediated by the microtubule (MT)-based mitotic spindle and∼ 200 essential MT-associated …
mediated by the microtubule (MT)-based mitotic spindle and∼ 200 essential MT-associated …
Mechanisms underlying spindle assembly and robustness
The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …
Following more than a century of study, many components and pathways contributing to …
Asymmetric molecular architecture of the human γ-tubulin ring complex
The γ-tubulin ring complex (γ-TuRC) is an essential regulator of centrosomal and
acentrosomal microtubule formation, yet its structure is not known. Here, we present a cryo …
acentrosomal microtubule formation, yet its structure is not known. Here, we present a cryo …
Microtubule minus-end-targeting proteins
A Akhmanova, CC Hoogenraad - Current Biology, 2015 - cell.com
Microtubules are cytoskeletal filaments that are intrinsically polarized, with two structurally
and functionally distinct ends, the plus end and the minus end. Over the last decade …
and functionally distinct ends, the plus end and the minus end. Over the last decade …
Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity
C Sánchez-Huertas, F Freixo, R Viais, C Lacasa… - Nature …, 2016 - nature.com
Neurons display a highly polarized microtubule network that mediates trafficking throughout
the extensive cytoplasm and is crucial for neuronal differentiation and function. In newborn …
the extensive cytoplasm and is crucial for neuronal differentiation and function. In newborn …
Microtubule nucleation at the centrosome and beyond
S Petry, RD Vale - Nature cell biology, 2015 - nature.com
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Microtubule nucleation: The waltz between γ-tubulin ring complex and associated proteins
Microtubules are essential cytoskeletal elements assembled from αβ-tubulin dimers. In high
eukaryotes, microtubule nucleation, the de novo assembly of a microtubule from its minus …
eukaryotes, microtubule nucleation, the de novo assembly of a microtubule from its minus …