Glaucoma-next generation therapeutics: impossible to possible

CM Adams, R Stacy, N Rangaswamy, C Bigelow… - Pharmaceutical …, 2019 - Springer
The future of next generation therapeutics for glaucoma is strong. The recent approval of two
novel intraocular pressure (IOP)-lowering drugs with distinct mechanisms of action is the first …

Electrophysiology in glaucoma

C Senger, R Moreto, SES Watanabe… - Journal of …, 2020 - journals.lww.com
Objectives: Electrophysiological testing of the visual system has been continuously used in
studies involving the evaluation of retinal ganglion cells and the diagnosis of glaucoma. This …

Ganglion cell loss in early glaucoma, as assessed by photopic negative response, pattern electroretinogram, and spectral-domain optical coherence tomography

B Cvenkel, M Sustar, D Perovšek - Documenta Ophthalmologica, 2017 - Springer
Purpose To evaluate discrimination ability of pattern electroretinography (PERG) and
photopic negative response (PhNR) between early glaucoma and healthy controls, and their …

Mimicking chronic glaucoma over 6 months with a single intracameral injection of dexamethasone/fibronectin-loaded PLGA microspheres

A Aragón-Navas, MJ Rodrigo, D Garcia-Herranz… - Drug Delivery, 2022 - Taylor & Francis
To create a chronic glaucoma animal model by a single intracameral injection of
biodegradable poly lactic-co-glycolic acid (PLGA) microspheres (Ms) co-loaded with …

A topical formulation of melatoninergic compounds exerts strong hypotensive and neuroprotective effects in a rat model of hypertensive glaucoma

M Dal Monte, M Cammalleri, R Amato… - International Journal of …, 2020 - mdpi.com
Melatonin is of great importance for regulating several eye processes, including pressure
homeostasis. Melatonin in combination with agomelatine has been recently reported to …

Measurable aspects of the retinal neurovascular unit in diabetes, glaucoma, and controls

RF Spaide - American Journal of Ophthalmology, 2019 - Elsevier
Purpose To study the structural and angiographic optical coherence tomography (OCT) data
of the macula from controls, patients with diabetes, and patients with glaucoma to evaluate …

A monoclonal anti-HMGB1 antibody attenuates neurodegeneration in an experimental animal model of glaucoma

H Tonner, S Hunn, N Auler, C Schmelter… - International Journal of …, 2022 - mdpi.com
Neuroinflammation is a crucial process for the loss of retinal ganglion cells (RGC), a major
characteristic of glaucoma. High expression of high-mobility group box protein 1 (HMGB1) …

The photopic negative response (PhNR): measurement approaches and utility in glaucoma

M Prencipe, T Perossini, G Brancoli… - International …, 2020 - Springer
Purpose Visual electrophysiological testing continues to generate interest among glaucoma
experts because of its potential help in clarifying disease pathophysiology and promoting …

Структурно-функциональные нарушения при глаукоме: перспективы доклинической диагностики. Часть 1. Насколько релевантен поиск того, что первично?

ВВ Нероев, МВ Зуева, АН Журавлева… - …, 2020 - ophthalmojournal.com
Аннотация В обзоре анализируются возможности современных технологий
структурной нейровизуализации сетчатки, стандартной периметрии и исследований …

The photopic negative response: an objective measure of retinal ganglion cell function in patients with Leber's hereditary optic neuropathy

R Karanjia, A Berezovsky, PY Sacai… - … & Visual Science, 2017 - iovs.arvojournals.org
Purpose: The photopic negative response (PhNR) is a slow negative component of a flash
photopic full-field ERG that has been shown to be specific for retinal ganglion cell (RGC) …