[HTML][HTML] Evidence for the benefits of melatonin in cardiovascular disease

M Tobeiha, A Jafari, S Fadaei, SMA Mirazimi… - Frontiers in …, 2022 - frontiersin.org
The pineal gland is a neuroendocrine gland which produces melatonin, a neuroendocrine
hormone with critical physiological roles in the circadian rhythm and sleep-wake cycle …

[HTML][HTML] Erectile dysfunction: pharmacological pathways with understudied potentials

DR Adam, MM Alem - Biomedicines, 2022 - mdpi.com
Erectile dysfunction (ED) is a public health concern worldwide. In the past, it was perceived
as a phenomenon attributed to age advancement. However, more individuals are affected …

[HTML][HTML] Melatonin protects diabetic heart against ischemia-reperfusion injury, role of membrane receptor-dependent cGMP-PKG activation

L Yu, W Di, X Dong, Z Li, Y Zhang, X Xue, Y Xu… - … et Biophysica Acta (BBA …, 2018 - Elsevier
It has been demonstrated that the anti-oxidative and cardioprotective effects of melatonin
are, at least in part, mediated by its membrane receptors. However, the direct downstream …

[HTML][HTML] Melatonin, a natural antioxidant therapy in spinal cord injury

L Xie, H Wu, X Huang, T Yu - Frontiers in Cell and Developmental …, 2023 - frontiersin.org
Spinal cord injury (SCI) is a sudden onset of disruption to the spinal neural tissue, leading to
loss of motor control and sensory function of the body. Oxidative stress is considered a …

Biomaterial strategies for limiting the impact of secondary events following spinal cord injury

TR Ham, ND Leipzig - Biomedical Materials, 2018 - iopscience.iop.org
The nature of traumatic spinal cord injury (SCI) often involves limited recovery and long-term
quality of life complications. The initial injury sets off a variety of secondary cascades, which …

[HTML][HTML] Proniosomal Gel-Loaded Phosphodiesterase Inhibitors (Sildenafil, Vardenafil, and Tadalafil): Prospects for Topical Penile Therapy of Tadalafil for Treatment …

SA Mohamed, RR Rofaeil, H Salem, M Elrehany… - Gels, 2023 - mdpi.com
Oral phosphodiesterase inhibitors have emerged as a game changer for the treatment of
erectile dysfunction (ED) since attaining FDA approval for its first member, sildenafil, in 1998 …

[HTML][HTML] Asiaticoside attenuates the effects of spinal cord injury through antioxidant and anti‑inflammatory effects, and inhibition of the p38‑MAPK mechanism

Y Luo, C Fu, Z Wang, Z Zhang… - Molecular Medicine …, 2015 - spandidos-publications.com
Asiaticoside has potent pharmacological activity and broader pharmacological effects,
including anti‑oxidant, antidepressant and hepatic protection effects, and the inhibition of …

[HTML][HTML] Melatonin for the treatment of spinal cord injury

Y Zhang, WX Zhang, YJ Zhang, YD Liu… - Neural regeneration …, 2018 - journals.lww.com
Spinal cord injury (SCI) from trauma or disease severely impairs sensory and motor function.
Neurorehabilitation after SCI is a complex medical process that focuses on improving …

Resveratrol treatment may preserve the erectile function after radiotherapy by restoring antioxidant defence mechanisms, SIRT1 and NOS protein expressions

TE Sener, HH Tavukcu, BM Atasoy, O Cevik… - International journal of …, 2018 - nature.com
Radiotherapy (RT) for prostate cancer (PC) can cause erectile dysfunction (ED) by
damaging neurovascular structures with oxidative stress. In this study, we evaluated the …

Melatonin for spinal cord injury in animal models: a systematic review and network meta-analysis

L Yang, M Yao, Y Lan, W Mo, Y Sun, J Wang… - Journal of …, 2016 - liebertpub.com
Spinal cord injury (SCI) leads to loss of function below the lesion and affects individuals
worldwide. An increasing number of experimental studies support the effectiveness of …