Human topoisomerases and their roles in genome stability and organization
Y Pommier, A Nussenzweig, S Takeda… - … Reviews Molecular Cell …, 2022 - nature.com
Human topoisomerases comprise a family of six enzymes: two type IB (TOP1 and
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …
Determinants of enhancer and promoter activities of regulatory elements
R Andersson, A Sandelin - Nature Reviews Genetics, 2020 - nature.com
The proper activities of enhancers and gene promoters are essential for coordinated
transcription within a cell. Although diverse methodologies have been developed to identify …
transcription within a cell. Although diverse methodologies have been developed to identify …
Origins of DNA replication in eukaryotes
Y Hu, B Stillman - Molecular cell, 2023 - cell.com
Errors occurring during DNA replication can result in inaccurate replication, incomplete
replication, or re-replication, resulting in genome instability that can lead to diseases such as …
replication, or re-replication, resulting in genome instability that can lead to diseases such as …
Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration
Persistent DNA double-strand breaks (DSBs) in neurons are an early pathological hallmark
of neurodegenerative diseases including Alzheimer's disease (AD), with the potential to …
of neurodegenerative diseases including Alzheimer's disease (AD), with the potential to …
The role of 3D genome organization in development and cell differentiation
In eukaryotes, the genome does not exist as a linear molecule but instead is hierarchically
packaged inside the nucleus. This complex genome organization includes multiscale …
packaged inside the nucleus. This complex genome organization includes multiscale …
Proteolysis-targeting chimeras as therapeutics and tools for biological discovery
GM Burslem, CM Crews - Cell, 2020 - cell.com
New biological tools provide new techniques to probe fundamental biological processes.
Here we describe the burgeoning field of proteolysis-targeting chimeras (PROTACs), which …
Here we describe the burgeoning field of proteolysis-targeting chimeras (PROTACs), which …
Computational methods for analysing multiscale 3D genome organization
Recent progress in whole-genome mapping and imaging technologies has enabled the
characterization of the spatial organization and folding of the genome in the nucleus. In …
characterization of the spatial organization and folding of the genome in the nucleus. In …
Control of DNA replication timing in the 3D genome
The 3D organization of mammalian chromatin was described more than 30 years ago by
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …
PHOTACs enable optical control of protein degradation
M Reynders, BS Matsuura, M Bérouti, D Simoneschi… - Science …, 2020 - science.org
PROTACs (PROteolysis TArgeting Chimeras) are bifunctional molecules that target proteins
for ubiquitylation by an E3 ligase complex and subsequent degradation by the proteasome …
for ubiquitylation by an E3 ligase complex and subsequent degradation by the proteasome …
Structural variations in cancer and the 3D genome
F Dubois, N Sidiropoulos, J Weischenfeldt… - Nature Reviews …, 2022 - nature.com
Structural variations (SVs) affect more of the cancer genome than any other type of somatic
genetic alteration but difficulties in detecting and interpreting them have limited our …
genetic alteration but difficulties in detecting and interpreting them have limited our …