Identification of collaborative cross mouse strains permissive to Salmonella enterica serovar Typhi infection

KR Alugupalli, S Kothari, MP Cravens, JA Walker… - Scientific Reports, 2023 - nature.com
Salmonella enterica serovar Typhi is the causative agent of typhoid fever restricted to
humans and does not replicate in commonly used inbred mice. Genetic variation in humans …

[PDF][PDF] Optimalisasi 1000 Hari Pertama Kehidupan: Nutrisi, Kasih Sayang, Stimulasi, dan Imunisasi Merupakan Langkah Awal Mewujudkan Generasi Penerus yang …

H Gunardi - EJournal Kedokteran Indonesia, 2021 - ejki.fk.ui.ac.id
Indonesia, sejak tahun 2020, sedang mengalami bonus demografi, ketika proporsi
penduduk usia produktif (15-64 tahun) lebih banyak dibandingkan proporsi penduduk usia …

A randomized, observer-blind, controlled phase III clinical trial assessing safety and immunological non-inferiority of VI-diphtheria Toxoid versus VI-tetanus Toxoid …

S Chaudhary, GS Shah, NK Bhatta… - Human Vaccines & …, 2023 - Taylor & Francis
Typhoid remains one of the major serious health concerns for children in developing
countries. With extremely drug-resistant cases emerging, preventative measures like …

[HTML][HTML] Typhoid Conjugate Vaccine: A Boon for Endemic Regions

N Agarwal, N Gupta, HS Surendra, T Dutta, M Mahajan - Cureus, 2024 - ncbi.nlm.nih.gov
Typhoid fever has the highest disease burden in countries in low-and middle-income
countries, primarily located in Asia and Sub-Saharan Africa. Previous typhoid vaccines such …

[HTML][HTML] The lack of natural IgM increases susceptibility and impairs anti-vi polysaccharide IgG responses in a mouse model of typhoid

AS Alugupalli, MP Cravens, JA Walker… - …, 2022 - journals.aai.org
Circulating IgM present in the body prior to any apparent Ag exposure is referred to as
natural IgM. Natural IgM provides protective immunity against a variety of pathogens …

TLR4 ligands in typhoid Vi polysaccharide subunit vaccines contribute to immunogenicity

KR Alugupalli - Immunohorizons, 2024 - journals.aai.org
Activation of B cells and T cells requires the engagement of costimulatory signaling
pathways in addition to Ag receptor signaling for efficient immune responses. None of the …

A TLR4 ligand-based adjuvant for promoting the immunogenicity of Typhoid subunit vaccines

KR Alugupalli - Frontiers in Immunology, 2024 - frontiersin.org
None of the typhoid Vi Polysaccharide (ViPS) subunit vaccines incorporate adjuvants, and
the immunogenicity of ViPS vaccines (eg Typbar TCV® and Typhim Vi®) is in part due to …

A phase II clinical trial of a Vi-DT typhoid conjugate vaccine in healthy Indonesian adolescents and adults: one-month evaluation of safety and immunogenicity

S Koesnoe, BE Medise, I Rengganis… - … , Travel Medicine and …, 2024 - Springer
Background Typhoid fever is commonly found until today, especially in developing
countries. It has fatal complications and measures must be taken to reduce the incidence of …

Typhoid Conjugate Vaccine: A Boon for Endemic Regions

A Nitesh, N Gupta, HS Surendra, D Trayambak… - Cureus, 2024 - search.proquest.com
Typhoid fever has the highest disease burden in countries in low-and middle-income
countries, primarily located in Asia and Sub-Saharan Africa. Previous typhoid vaccines such …

Drugs, Vaccines and Druggable Targets of Salmonella Typhi

E Ndezure, I Ibrahim, J Abugri, J Ayariga - 2023 - preprints.org
Despite recent public health and hygiene advancements, enteric fever, commonly referred to
as typhoid fever, remains a common disease in developing nations. The common mode of …