Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet
of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular …

Phosphoinositides serve as signature motifs for different cellular membranes and often are
required for the function of membrane proteins. Here, we summarize clear evidence …

Pneumonia, such as acute lung injury (ALI), has been a type of lethal disease that is
generally caused by uncontrolled inflammatory response and excessive generation of …

The interactions between mathematics and physiology have a long and illustrious history, of
which the study of calcium signalling is but a small chapter. Nevertheless, for those involved …

We conducted a large-scale functional genetic study to characterize mechanisms of
resistance to ALK inhibition in ALK-dependent lung cancer cells. We identify members of …

The stabilization of different active conformations of G protein–coupled receptors is thought
to underlie the varying efficacies of biased and balanced agonists. Here, profiling the …

Abstract Phosphoinositide-specific phospholipase Cs (PLCs) are expressed in all
mammalian cells and play critical roles in signal transduction. To obtain a comprehensive …

G-protein-coupled receptors (GPCRs) are known to play central roles in the physiology of
many organisms. Members of this seven α-helical transmembrane protein family transduce …

Phosphoinositides are rapidly turning-over phospholipids that play key roles in intracellular
signaling and modulation of membrane effectors. Through technical refinements we have …

The phosphoinositide, phosphatidylinositol 4, 5-bisphosphate (PIP2), has long been
established as a major contributor to intracellular signaling, primarily by virtue of its role as a …