Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

Resolution of inflammation is a coordinated and active process aimed at restoration of tissue
integrity and function. This review integrates the key molecular and cellular mechanisms of …

Immune responses rely on the rapid and coordinated migration of leukocytes. Whereas it is
well established that single-cell migration is often guided by gradients of chemokines and …

Plasticity and functional polarization are hallmarks of the mononuclear phagocyte system.
Here we review emerging key properties of different forms of macrophage activation and …

Mononuclear phagocytes are versatile cells that can express different functional programs in
response to microenvironmental signals. Fully polarized M1 and M2 (or alternatively …

CAR T cell therapy remains ineffective in solid tumors, due largely to poor infiltration and T
cell suppression at the tumor site. T regulatory (Treg) cells suppress the immune response …

This article is part of a Minifocus on collective cell migration. For further reading, please see
related articles: ʻMechanisms of collective cell migration at a glanceʼ by Olga Ilina and …

To assess the importance of B cell control of T cell differentiation, we analyzed the course of
the T helper type 1 (TH1)-driven disease experimental autoimmune encephalomyelitis in …

▪ Abstract Chemokines compose a sophisticated communication system used by all our cell
types, including immune cells. Chemokine messages are decoded by specific receptors that …

Chemokines play well established roles as attractants of naïve and effector T cells. New
studies indicate that chemokines also have roles in regulating T cell differentiation. Blocking …