The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …

Conspectus Clustered, regularly interspaced, short palindromic repeat (CRISPR)/associated
protein 9 (CRISPR/Cas9) is emerging as a powerful genome-editing tool, enabling precise …

The development of a dynamic chemistry toolbox to endow materials dynamic behavior has
been key to the rational design of future smart materials. The rise of supramolecular and …

Sulfur can form diverse S (IV) and S (VI) stereogenic centers, of which some have gained
significant attention recently due to their increasing use as pharmacophores in drug …

DNA aptamers have been widely used as biosensors for detecting a variety of targets.
Despite decades of success, they have not been applied to monitor any targets in plants …

The delivery of functional proteins remains a major challenge in advancing biological and
pharmaceutical sciences. Herein, we describe a powerful, simple, and highly effective …

Oligonucleotide phosphorothioates (OPS) are DNA or RNA mimics where one phosphate
oxygen is replaced by a sulfur atom. They have been shown to enter mammalian cells much …

Endosomal entrapment has remained the major bottleneck for cytosolic delivery of
nanoparticle‐based delivery systems. Uncovering fundamentally new pathways for …

New preparation methods of vectors are the key to developing the next generation of
biomacromolecule delivery systems. In this study, a controllable disulfide exchange …

Intracellular protein delivery is highly desirable for protein drug‐based cell therapy.
Established technologies suffer from poor cell‐specific cytosolic protein delivery, which …