More than two decades have passed since genetically modified HIV was used for gene
delivery. Through continuous improvements these early marker gene-carrying HIVs have …

Publisher Summary This chapter focuses on recent biochemical and biophysical studies that
examine the nucleic acid chaperone function of HIV‐1 nucleocapsid protein (NC) and its …

The crystal structure of the protease of the human immunodeficiency virus type 1 (HIV-1),
which releases structural proteins and enzymes from viral polyprotein products, has been …

A nuclear encoded mitochondrial heat-shock protein hsp60 is required for the assembly into
oligomeric complexes of proteins imported into the mitochondrial matrix. hsp60 is a member …

Covalent linkage of myristic acid to the N-terminal glycine residue of Pr55gag, the precursor
of the major structural proteins of human immunodeficiency virus 1 (HIV-1), facilitates an …

The unprocessed Gag precursor from HIV-l, when expressed in recombinant baculovirus-
infected insect cells, is targeted to the plasma membrane and assembles in loo-120 nm …

The three-dimensional structure of the human immunodeficiency virus–type 1 (HIV-1)
nucleocapsid protein (NC) bound to the SL3 stem-loop recognition element of the genomic …

Mutations in sequences at the C terminus of the capsid precursor protein of human
immunodeficiency virus type 1 that affect the viral p6 protein prevent release of budded virus …

The human immunodeficiency virus type 1 (HIV-1) Gag protein precursor, Pr55Gag, contains
at its C-terminal end a proline-rich, 6-kDa domain designated p6. Two functions have been …

New HIV therapies are urgently needed to address the growing problem of drug resistance.
In this article, we characterize the anti-HIV drug candidate 3-O-(3′, 3′-dimethylsuccinyl) …