The interaction of cells and tissues with artificial materials designed for applications in
biotechnologies and in medicine is governed by the physical and chemical properties of the …

Focal adhesions lie at the convergence of integrin adhesion, signaling and the actin
cytoskeleton. Cells modify focal adhesions in response to changes in the molecular …

The transforming growth factor-β (TGF-β) signaling pathway is often misregulated during
cancer progression. In early stages of tumorigenesis, TGF-β acts as a tumor suppressor by …

Interactions between cells and the extracellular matrix are at the core of tissue engineering
and biology. However, most studies of these interactions have used traditional two …

Breast epithelial cells differentiate into tubules when cultured in floating three-dimensional
(3D) collagen gels, but not when the cells are cultured in the same collagen matrix that is …

Focal adhesion (FA) assembly, mediated by integrin activation, responds to matrix stiffness;
however, the underlying mechanisms are unclear. Here, we showed that β1 integrin and …

The ability of cells to migrate within the extracellular matrix and to remodel it depends as
much on the physical and biochemical characteristics of a particular matrix as on cellular …

Many cell types respond to forces as acutely as they do to chemical stimuli, but the
mechanisms by which cells sense mechanical stimuli and how these factors alter cellular …

We reconstituted type I collagen nanofibers prepared by electrospin technology and
examined the morphology, growth, adhesion, cell motility, and osteogenic differentiation of …

Fluorescence proteins (FPs) have been widely used for live-cell imaging in the past decade.
This review summarizes the recent advances in FP development and imaging technologies …