The most frequent adult-type primary CNS tumours are diffuse gliomas, but a large variety of
rarer CNS tumour types exists. The classification of these tumours is increasingly based on …

Medulloblastoma (MB) is the most common CNS embryonal tumor. While the overall cure
rate is around 70%, patients with high‐risk disease continue to have poor outcome and …

Glioblastoma multiforme is the most lethal intrinsic brain tumor. Even with the existing
treatment regimen of surgery, radiation, and chemotherapy, the median survival time is only …

Li–Fraumeni syndrome (LFS) is a hereditary tumor that exhibits autosomal dominant
inheritance. LFS develops in individuals with a pathogenic germline variant of the cancer …

Corticotroph macroadenomas are rare but difficult to manage intracranial neoplasms.
Mutations in the two Cushing's disease mutational hotspots USP8 and USP48 are less …

Brain tumors are an abnormal growth of cells in the brain, also known as multifactorial
groups of neoplasm. Incidence rates of brain tumors increase rapidly, and it has become a …

p53 is one of the most intensively studied tumor suppressors. It transcriptionally regulates a
broad range of genes to modulate a series of cellular events, including DNA damage repair …

Simple Summary Medulloblastoma is the commonest malignant brain tumour of childhood.
Disease relapse following maximal multi-modal therapy including upfront craniospinal …

OBJECTIVE. Li-Fraumeni syndrome (LFS) is a rare autosomal-dominant inherited syndrome
containing a germline mutation in the TP53 gene, which predisposes to oncogenesis …

Li Fraumeni syndrome (LFS) is a hereditary cancer predisposition syndrome caused by
germline mutations in TP53. TP53 is the most common mutated gene in human cancer …