Antioxidant peptides, the guardian of life from oxidative stress

Y Zhu, K Wang, X Jia, C Fu, H Yu… - Medicinal Research …, 2024 - Wiley Online Library
Reactive oxygen species (ROS) are produced during oxidative metabolism in aerobic
organisms. Under normal conditions, ROS production and elimination are in a relatively …

Sulfonamide inhibitors: a patent review 2013-present

İ Gulçin, P Taslimi - Expert opinion on therapeutic patents, 2018 - Taylor & Francis
Introduction: Sulfonamide compounds are significant class of synthetic bacteriostatic
antibiotics still which used today for the therapy of bacterial infections and those caused by …

Synthesis, characterization, inhibition effects, and molecular docking studies as acetylcholinesterase, α-glycosidase, and carbonic anhydrase inhibitors of novel …

N Lolak, S Akocak, C Türkeş, P Taslimi, M Işık… - Bioorganic …, 2020 - Elsevier
Some metabolic enzyme inhibitors can be used in the treatment of many diseases.
Therefore, synthesis and determination of alternative inhibitors are essential. In this study …

Anticholinergic, antidiabetic and antioxidant activities of Anatolian pennyroyal (Mentha pulegium)-analysis of its polyphenol contents by LC-MS/MS

İ Gülçin, AC Gören, P Taslimi, SH Alwasel… - Biocatalysis and …, 2020 - Elsevier
Methanol and water extracts of pennyroyal (Mentha pulegium) were evaluated for their
antioxidant profiles by eight distinguished bioanalytical methods and for their inhibitory …

Synthesis, biological evaluation, and in silico study of novel library sulfonates containing quinazolin‐4(3H)‐one derivatives as potential aldose reductase inhibitors

FS Tokalı, Y Demir, İH Demircioğlu… - Drug Development …, 2022 - Wiley Online Library
A series of novel sulfonates containing quinazolin‐4 (3 H)‐one ring derivatives was
designed to inhibit aldose reductase (ALR2, EC 1.1. 1.21). Novel quinazolinone derivatives …

Anticholinergic, antidiabetic and antioxidant activities of cinnamon (cinnamomum verum) bark extracts: polyphenol contents analysis by LC-MS/MS

I Gulcin, R Kaya, AC Goren, H Akincioglu… - … Journal of Food …, 2019 - Taylor & Francis
Ethanolic (EEC) and aqueous (WEC) extracts of cinnamon (Cinnamomum verum) were
evaluated for their antioxidant profiles by eight distinguished bioanalytical antioxidant …

Investigation of inhibitory properties of some hydrazone compounds on hCA I, hCA II and AChE enzymes

K Kucukoglu, HI Gul, P Taslimi, I Gulcin… - Bioorganic chemistry, 2019 - Elsevier
Recently, inhibition of carbonic anhydrase (hCA) and acetylcholinesterase (AChE) have
appeared as a promising approach for pharmacological intervention in a variety of disorders …

The antidiabetic and anticholinergic effects of chrysin on cyclophosphamide‐induced multiple organ toxicity in rats: Pharmacological evaluation of some metabolic …

P Taslimi, FM Kandemir, Y Demir… - … of biochemical and …, 2019 - Wiley Online Library
Abstract Chrysin (CH) or 5, 7‐dihydroxyflavone is a flavonoid present in various plants, bee
propolis, and honey. Cyclophosphamide (CYP) is a chemotherapeutic drug, which is …

Novel thymol bearing oxypropanolamine derivatives as potent some metabolic enzyme inhibitors–Their antidiabetic, anticholinergic and antibacterial potentials

M Zengin, H Genc, P Taslimi, A Kestane, E Guclu… - Bioorganic …, 2018 - Elsevier
A series of classical and newly synthesized thymol bearing oxypropanolamine compounds
were synthesized and characterized. Their in vitro antibacterial activity on A. baumannii, P …

The impact of some natural phenolic compounds on carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and α‐glycosidase enzymes: An antidiabetic …

P Taslimi, C Caglayan, İ Gulcin - Journal of biochemical and …, 2017 - Wiley Online Library
Natural products from food and plant sources have been used for medicinal usage for ages.
Also, natural products with therapeutic significance are compounds derived from animals …