Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an
atherosclerotic plaque. According to the 'response to injury'and 'vulnerable …

Oxygenated derivatives of cholesterol (oxysterols) present a remarkably diverse profile of
biological activities, including effects on sphingolipid metabolism, platelet aggregation …

The beneficial effects of statins are assumed to result from their ability to reduce cholesterol
biosynthesis. However, because mevalonic acid is the precursor not only of cholesterol, but …

Libby P (Brigham and Women's Hospital and Harvard Medical School, Boston,
Massachusetts, USA). Changing concepts of atherogenesis (Minisymposium: Review). J …

Abdominal aortic aneurysms (AAAs) are characterized by structural deterioration of the
aortic wall leading to progressive aortic dilatation and eventual rupture. The …

Background—The specific role of apoptosis in human atherosclerosis remains unknown.
During apoptotic cell death, phosphatidylserine exposure on the cell surface confers a high …

Since Kerr et al1 in 1972 coined the term “apoptosis” for a morphologically distinct mode of
cell death, this concept of cell suicide has gained increasing interest in cytology and …

The ability of gene targeting in the mouse species presents a powerful tool to determine the
role of specific molecules in vascular biology. Using a denuding-injury procedure, we …

Platelet-derived growth factor (PDGF) was identified in a search for serum factors that
stimulate smooth muscle cell (SMC) proliferation. During the development of lesions of …

Whereas unperturbed endothelial cells provide potent anticoagulant properties, exposure to
inflammatory and atherogenic stimuli can rapidly lead to a procoagulant behavior. Because …