[HTML][HTML] Current landscape in the discovery of novel antibacterial agents

J Vila, J Moreno-Morales… - Clinical Microbiology and …, 2020 - Elsevier
Background Standard treatments against bacterial infections are becoming ineffective due to
the rise of antibacterial resistance worldwide. Classical approaches to develop new …

Emerging and future strategies in the management of recalcitrant Candida auris

N Bandara, L Samaranayake - Medical Mycology, 2022 - academic.oup.com
Candida auris is an emerging, multi drug resistant fungal pathogen that has caused
infectious outbreaks in over 45 countries since its first isolation over a decade ago, leading …

From marine metabolites to the drugs of the future: Squalamine, trodusquemine, their steroid and triterpene analogues

O Kazakova, G Giniyatullina, D Babkov… - International journal of …, 2022 - mdpi.com
This review comprehensively describes the recent advances in the synthesis and
pharmacological evaluation of steroid polyamines squalamine, trodusquemine, ceragenins …

[HTML][HTML] Small molecules for combating multidrug-resistant superbug Candida auris infections

J Tu, N Liu, Y Huang, W Yang, C Sheng - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Candida auris is emerging as a major global threat to human health. C. auris infections are
associated with high mortality due to intrinsic multi-drug resistance. Currently, therapeutic …

Ceragenins exhibit antiviral activity against SARS-CoV-2 by increasing the expression and release of type I interferons upon activation of the host's immune response

Ł Suprewicz, A Szczepański, M Lenart, E Piktel… - Antiviral Research, 2023 - Elsevier
The COVID-19 pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2) heavily burdened the entire world socially and economically. Despite a …

Efficacy of Ceragenins in Controlling the Growth of Oral Microorganisms: Implications for Oral Hygiene Management

M Czarnowski, M Słowińska, M Sawieljew… - Pharmaceuticals, 2024 - mdpi.com
Ensuring proper dental hygiene is of paramount importance for individuals' general well-
being, particularly for patients receiving medical care. There is a prevailing utilization of …

Antibiofilm activities of ceragenins and antimicrobial peptides against fungal-bacterial mono and multispecies biofilms

M Hacioglu, O Oyardi, C Bozkurt-Guzel… - The Journal of …, 2020 - nature.com
Multispecies biofilms, in which both fungus and bacteria species can be present, play a
significant role in persistent infections, and new therapeutic options are needed against …

Use of ceragenins as a potential treatment for urinary tract infections

U Wnorowska, E Piktel, B Durnaś, K Fiedoruk… - BMC infectious …, 2019 - Springer
Abstract Background Urinary tract infections (UTIs) are one of the most common bacterial
infections. High recurrence rates and the increasing antibiotic resistance among …

New β-lactam antibiotics and ceragenins–a study to assess their potential in treatment of infections caused by multidrug-resistant strains of Pseudomonas aeruginosa

P Paprocka, B Durnaś, A Mańkowska… - Infection and Drug …, 2021 - Taylor & Francis
Background The increasing number of infections caused by antibiotic resistant strains of
Pseudomonas aeruginosa posed a very serious challenge for clinical practice. This standing …

Mechanisms of Antibiotic Resistance and Developments in Therapeutic Strategies to Combat Klebsiella pneumoniae Infection

Y Li, S Kumar, L Zhang - Infection and Drug Resistance, 2024 - Taylor & Francis
Infections with drug-resistant bacteria have become one of the greatest public health
challenges, and K. pneumoniae is among the top six drug-resistant bacteria. K. pneumoniae …