Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …

The ongoing search for therapeutic interventions in Alzheimer disease (AD) has highlighted
the complexity of this condition and the need for additional biomarkers, beyond amyloid-β …

The nitric oxide (NO)/cGMP pathway has been extensively studied for its pivotal role in
synaptic plasticity and memory processes, resulting in an increase of cAMP response …

The basal forebrain cholinergic system (BFCS) has long been implicated in age-related
cognitive changes and the pathophysiology of Alzheimer's disease (AD). Limitations of …

Cholinergic innervation of the hippocampus uses the neurotransmitter acetylcholine (ACh)
to coordinate neuronal circuit activity while simultaneously influencing the function of non …

CHRFAM7A is a relatively recent and exclusively human gene arising from the partial
duplication of exons 5 to 10 of the α7 neuronal nicotinic acetylcholine receptor subunit (α7 …

Nicotinic acetylcholine receptors (nAChRs) are widely expressed in or on various cell types
and have diverse functions. In immune cells nAChRs regulate proliferation, differentiation …

Long COVID, also called post-acute sequelae of SARS-CoV-2, is characterized by a
multitude of lingering symptoms, including impaired cognition, that can last for many months …

Initiated by findings that Alzheimer's disease is associated with a profound loss of
cholinergic markers in human brain, decades of studies have examined the interactions …

Amyloid-β (Aβ) accumulation and tauopathy are considered the pathological hallmarks of
Alzheimer's disease (AD), but attenuation in choline signaling, including decreased nicotinic …